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Frontier Biotech's Long-acting HIV-1 Fusion Inhibitor Albuvirtide Meets 48-Week Primary Objective: Interim Results of a Phase 3 Trial

Frontier Biotechnologies Inc. today reported that a phase 3 clinical trial (TALENT Study) of its lead product albuvirtide meets primary objective based on an interim analysis. The results demonstrated that once-weekly given albuvirtide plus ritonavir-boosted lopinavir was non-inferior to WHO-recommended second-line three-drug regimen (control) at 48-week in treatment experienced HIV-1 infected adults. In addition, patients administered with albuvirtide showed statistically better renal safety than those taking the control regimen containing tenofovir disoproxil fumarate.

Published
07 June 2016
From
Frontier Biotech press release
Botswana gets GSK's modern HIV drug in largest ever Africa tender

ViiV Healthcare, which is majority-owned by GSK, said on Friday it was the first time that Tivicay, or dolutegravir, was being made available as a first-line treatment as part of a national health program in sub-Saharan Africa.

Published
03 June 2016
From
Reuters
Fearing Drugs’ Rare Side Effects, Millions Take Their Chances With Osteoporosis

Millions of Americans are missing out on a chance to avoid debilitating fractures from weakened bones, researchers say, because they are terrified of exceedingly rare side effects from drugs that can help them.

Published
02 June 2016
From
New York Times
Kremlin Experts Blame Condoms for Russian HIV Epidemic

Kremlin-backed experts have described condoms as the main cause of Russia HIV epidemic, the Kommersant newspaper reported Tuesday. The report from the Russian Institute for Strategic Research (RISR) described the country's HIV problem as part of information war against Russia.

Published
01 June 2016
From
Moscow Times
Two million people with HIV started treatment in 2015

At least two million people worldwide started antiretroviral treatment in 2015 alone, and 17 million people are now taking antiretroviral therapy, up by a third since 2013,

Published
31 May 2016
By
Keith Alcorn
Very high levels of drug resistance seen in people experiencing first-line antiretroviral therapy failure in Kenya

A cross-sectional survey of viral load in patients attending the largest HIV clinic in Kenya has shown that after an average of nearly two years

Published
31 May 2016
By
Gus Cairns
A question of timing: A lawsuit claims Gilead Sciences could have developed a less-harmful version of its HIV treatment sooner

More than a decade ago, researchers at Gilead Sciences thought they had a breakthrough: a new version of the company’s key HIV medicine that was less toxic to kidneys and bones. But in 2004 Gilead executives stopped the research, only to restart it as the expiration of tenofovir’s patent in 2018 neared.

Published
30 May 2016
From
Los Angeles Times
Rare but severe liver side-effects reported among South African patients starting efavirenz-based ART

Treatment with efavirenz has been associated with rare but severe liver complications among patients receiving antiretroviral therapy (ART) in South Africa. Writing in AIDS, investigators report three patterns

Published
27 May 2016
By
Michael Carter
HIV/HBV co-infection linked to worse immune recovery and death, but tenofovir improves outcomes

HIV-positive people with hepatitis B virus (HBV) co-infection had impaired CD4 cell recovery after starting antiretroviral therapy (ART) and a higher risk of death than those without

Published
23 May 2016
By
Liz Highleyman
In Option B+, side-effects and needing time to think are key reasons for not taking HIV medication

A qualitative study of women in Malawi who chose not to take HIV treatment as part of the country’s Option B+ programme, or who interrupted their treatment,

Published
19 May 2016
By
Roger Pebody

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