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Six questions about HIV/AIDS that deserve more attention

As HIV investigators work to control and eradicate the virus worldwide, certain myths or misconceptions about the disease have been embraced, whereas other concepts with merit have been left relatively unexplored, argues American HIV/AIDS researcher Jay Levy, M.D., in a Trends in Molecular Medicine commentary. He calls on fellow researchers to continue questioning and not to lose sight of alternative strategies that could ultimately lead to a sustainable, long-term solution to HIV infection.

Published
15 April 2015
From
Eurekalert Inf Dis
Human immune system can control re-awakened HIV, suggesting ‘kick and kill’ cure is possible

The human immune system can handle large bursts of HIV activity and so it should be possible to cure HIV with a ‘kick and kill’ strategy, finds new research led by UCL, the University of Oxford and the University of North Carolina at Chapel Hill.

Published
14 April 2015
From
University College London press release
Mechanism of action of ABIVAX’s First-in-class anti-HIV drug published today in peer-reviewed journal Retrovirology

ABX464 blocks viral replication by preventing the export of viral RNA from the nucleus to the cytoplasm in infected cells. This transport is normally mediated by a viral protein called Rev, and the activity of Rev is efficiently inhibited by ABX464. Never targeted before, Rev has been postulated of potential interest for HIV treatment for some time, but ABX464 is the first molecule under development aimed at inhibiting it.

Published
14 April 2015
From
ABIVAX press release
Editing HIV out of our genome with CRISPR

In an attempt to render latent HIV completely harmless, UMass Medical School researchers are using CRISPR/Cas9, a powerful gene editing tool, to develop a novel technology that can potentially cut the DNA of the latent virus out of an infected cell.

Published
13 April 2015
From
University of Massacusetts Medical Schoool press release
An HIV Cure and a Vaccine within the Next 15 Years?

Earlier this year, Bill Gates caused a ripple in the media by expressing optimism that a vaccine and a cure for HIV will become a reality within the next 15 years. From TAG’s perspective, Gates’s buoyancy does have some scientific basis—there have been encouraging signs of progress on both the vaccine and cure fronts in recent years—but the challenges that lie ahead must not be underestimated.

Published
13 April 2015
From
Treatment Action Group
Broadly Neutralizing Antibody Suppresses HIV in Clinical Trial

There is now intense interest in learning whether the blossoming array of broadly neutralizing antibodies (bNAbs) can be put to therapeutic and preventive use. A paper published yesterday in Nature describes encouraging results from a phase I trial involving the bNAb 3BNC117. Reflecting the level of interest in the topic, the paper has attracted extensive press coverage.

Published
10 April 2015
From
TAG
'This is what it's really like to live with HIV'

The number of young men being diagnosed with HIV has doubled in ten years; the number of new diagnoses among gay and bisexual men has reached a record high, according to the most recent data. The virus is rarely out of the news, and yet, because of continuing developments in treatment, few of us understand what life with the condition is like now. Three young men, all diagnosed in their 20s, talk about living with the virus.

Published
10 April 2015
From
Daily Telegraph
‘Medic’ who says he can cure Ebola, Aids and autism with bleach enema is coming to the UK

Jim Humble, who calls himself the Archbishop of the Genesis II Church of Health and Healing, is due to speak at the Spirit of Health conference in Seaford, East Sussex. But campaigners want organisers to prevent him from promoting his goods.

Published
10 April 2015
From
Metro
Women in PrEP trial feared they would have to leave study if they reported low adherence

Post-study interviews and computer questionnaires conducted with former participants in a trial of pre-exposure prophylaxis (PrEP) that reported zero effectiveness show that participants concealed their low adherence to

Published
10 April 2015
By
Gus Cairns
In first human study, new antibody therapy shows promise in suppressing HIV infection

The new study, conducted in Michel Nussenzweig’s Laboratory of Molecular Immunology, finds that administration of a potent antibody, called 3BNC117, can catch HIV off guard and reduce viral loads.

Published
09 April 2015
From
Rockefeller University press release
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