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Drug interactions and pharmacokinetics news

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Sofosbuvir/velpatasvir for hepatitis C can be administered with most antiretrovirals

Sofosbuvir/velpatasvir, a forthcoming combination that effectively treats all hepatitis C virus (HCV) genotypes, can be safely used with most boosted antiretrovirals for people with HIV and HCV

Published
14 March 2016
By
Liz Highleyman
Transgender people are at high risk for HIV, but too little is known about prevention and treatment for this population

Transgender women have among the highest rates of HIV infection but little is known about HIV prevalence among trans men, Tonia Poteat of Johns Hopkins Bloomberg School

Published
11 March 2016
By
Liz Highleyman
Women need more of the HIV drug Truvada than men to prevent infection

Women need daily doses of the antiviral medication Truvada to prevent HIV infection while men only need two doses per week due to the way the drug accumulates in different body tissues, according to a new study from pharmacy researchers the University of North Carolina at Chapel Hill.

Published
04 March 2016
From
Eurekalert Medicine & Health
Almost-certain case of PrEP failure due to drug resistance reported at CROI 2016

A case report of a man in Toronto who became infected with a multi-drug-resistant strain of HIV despite apparently very consistent adherence to PrEP was presented at

Published
25 February 2016
By
Gus Cairns
Study: HIV can hide and grow in 'sanctuaries' in body after it's undetectable in blood

The latest study appears to show a different type of "sanctuary," as the researchers called it, harboring cells with low levels of HIV replication that move into the blood. This suggests that virus growth could occur in a place where drug concentrations are very low.

Published
28 January 2016
From
Washington Post
People taking a large number of non-HIV-related medications more likely to stop or change HIV drugs

HIV-positive patients who are taking a large number of medications for the treatment of non-HIV-related conditions are at increased risk of stopping or changing their antiretroviral therapy (ART),

Published
27 January 2016
By
Michael Carter
Many patients on new HCV medications at risk of drug-drug interactions

Many patients taking direct acting antivirals (DAA) to treat hepatitis C virus (HCV) are at risk of clinically significant drug-drug interactions (DDIs), new research shows.

Published
23 December 2015
From
Medscape (requires free registration)
Study reveals potential challenges for scaling up of HCV therapy in UK

A large proportion of patients with chronic hepatitis C virus (HCV) infection in the UK have co-morbidities, hazardous use of drugs and alcohol and are taking medications that

Published
24 November 2015
By
Michael Carter
How do we maximise global HIV treatment access? IAPAC Care Continuum Guidelines make recommendations

IAPAC, the International Association of Practitioners in AIDS Care, has issued a set of guidelines that aims to establish a common set of best practices to ensure

Published
09 November 2015
By
Gus Cairns
Oestrogen may block HIV reactivation, hints at gender differences in viral reservoirs

Oestrogen receptors on cells may play a role in HIV latency and reactivation, and drugs targeting these receptors could potentially be used to either promote reactivation of

Published
08 September 2015
By
Liz Highleyman
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