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Large-Scale HIV Vaccine Trial to Launch in South Africa

The US National Institute of Allergy and Infectious Diseases (NIAID) and its partners have decided to advance an experimental HIV vaccine regimen into a large clinical trial, the first for seven years. This new study, called HVTN 702, is designed to determine whether the vaccine is safe, tolerable and effective at preventing HIV infection among South African adults. The trial will begin in November 2016, pending regulatory approval. It will recruit 5400 HIV-uninfected men and women aged 18 to 35 years who are at risk for HIV infection.

Published
18 May 2016
From
National Institute of Allergy and Infectious Diseases
Do ethicists hinder HIV prevention research?

Ethics panels may be hindering HIV prevention efforts by requiring gay and bisexual adolescents to get parental consent before taking part in research, experts suggest.

Published
21 April 2016
From
Reuters
Maraviroc may work as PrEP in combination with another drug – but probably not by itself

Two studies presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2016) outlined the first findings from the NEXT-PrEP study, otherwise known as HPTN 069.

Published
03 March 2016
By
Gus Cairns
‘On-demand’ rectal microbicide gel has reasonable tolerability and acceptability – daily less so

Results from the MTN-017 study of 1% tenofovir gel as a rectal microbicide were presented to the Conference on Retroviruses and Opportunistic Infections (CROI 2016) on

Published
28 February 2016
By
Gus Cairns
Condom use in French PrEP trial: half only used PrEP, a quarter used condoms and PrEP, one in six used neither

An analysis of condom use in the placebo-controlled phase of the French IPERGAY trial of intermittent pre-exposure prophylaxis (PrEP), presented at the Conference on Retroviruses and Opportunistic

Published
26 February 2016
By
Gus Cairns
Women under-represented in HIV clinical trials

Less than a quarter of people taking part in clinical trials for antiretroviral medications are women, potentially limiting the generalisability of findings, according to a systematic review

Published
08 February 2016
By
Roger Pebody
New PrEP studies will be a challenge, statisticians warn

Two statisticians involved in the PROUD and iPrEx trials of pre-exposure prophylaxis (PrEP) warn that future trials to test new PrEP drugs and formulations may be extremely difficult

Published
26 January 2016
By
Gus Cairns
Collaboration and Conflict: Looking Back at the 30-Year History of the AIDS Clinical Trials Group

The AIDS Clinical Trials Group (ACTG) supported groundbreaking research that transformed a death-sentence disease into a chronic illness that could be managed for decades with medication. It is now the largest network of therapeutic clinical trial units in the world.

Published
23 December 2015
From
JAMA
NIH drops special 10% set-aside for AIDS research

In a major shakeup for the HIV/AIDS research community, the National Institutes of Health (NIH) today announced it will no longer support setting aside a fixed 10% of its budget—or $3 billion this year—to fund research on the disease. The agency also plans to reprogram $65 million of its AIDS research grant funding this year to focus more sharply on ending the epidemic.

Published
15 December 2015
From
Science
New PrEP trial aims to 'virtually eliminate' new HIV infections in New South Wales by 2020

NSW will become the first state in Australia to implement such a rapid and large-scale trial of HIV pre-exposure prophylaxis.

Published
01 December 2015
From
UNSW press release
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