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CROI 2012 news

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Statins may slightly reduce non-AIDS events and death

Cholesterol-lowering statin drugs showed a trend toward lowering the risk of non-AIDS events and death among people with HIV in a large US cohort, researchers reported last week

Published
14 March 2012
By
Liz Highleyman
Metformin reduces artery plaque in HIV-positive people with metabolic syndrome

The diabetes drug metformin can help stall progression of calcium buildup in the coronary arteries of HIV-positive people with metabolic abnormalities, potentially reducing their risk of cardiovascular events,

Published
14 March 2012
By
Liz Highleyman
Studies look at interactions between new hepatitis C drugs and HIV antiretrovirals

Drug-drug interactions between direct-acting antiviral agents for hepatitis C and some antiretroviral medications used to treat HIV are common, but are often modest and can be managed

Published
14 March 2012
By
Liz Highleyman
Early infant diagnosis for HIV: is it taking place early enough?

Current early infant diagnosis (EID) protocols may need to be revised in the light of current WHO guidelines on the prevention and treatment of HIV-infection in low-resourced

Published
13 March 2012
By
Theo Smart
Elvitegravir Quad pill matches efavirenz and atazanavir combos

The Quad single-tablet regimen, an all-in-one pill containing the experimental integrase inhibitor elvitegravir plus two other antiretroviral drugs and a novel boosting agent, was as effective as

Published
13 March 2012
By
Liz Highleyman
KS in Africa: people with low CD4 counts still at risk despite ART

The incidence of Kaposi’s Sarcoma (KS) among HIV-infected adults on ART in Uganda and Kenya remains high (346 per 100,000 person-years) until the CD4 cell count rises above

Published
13 March 2012
By
Carole Leach-Lemens
Protease inhibitor not superior to NNRTI in sub-Saharan Africa

Protease inhibitor-based treatment did not result in superior rates of viorologic suppression after two years when compared to NNRTI-based treatment when tested in a randomised

Published
13 March 2012
By
Carole Leach-Lemens
Community-level preventive TB therapy in South African gold miners fails to bring down overall incidence

Individuals still saw TB incidence reduction of two-thirds, but effect was not durable Preliminary results from the Thibela Project – which looked at whether community-wide provision of isoniazid preventive therapy (IPT) in South African gold mines would improve TB control in these high-incidence sites.

Published
12 March 2012
From
Science Speaks
HIV brain impairment: who gets it, and why?

A number of papers at the 19th Conference on Retroviruses and Opportunistic Infections presented advances in research on HIV-related brain impairment and neurocognitive problems. A couple of problems

Published
12 March 2012
By
Gus Cairns
Zostavax Shingles Vaccine Generally Safe, Increases Antibody Levels, in People With Stable HIV

Two doses of Zostavax, a vaccine against shingles (herpes zoster), administered six weeks apart is “generally safe” for people living with HIV with CD4 counts of 200 or higher and undetectable viral loads, according to study results shared Wednesday, March 7, at the 19th Conference on Retroviruses and Opportunistic Infections (CROI).

Published
12 March 2012
From
AIDSMeds
Cancers in people with HIV: who gets them, and which ones?

A very low CD4 count in the past, and a history of smoking, are the most consistent risk factors to emerge from large studies of risks

Published
12 March 2012
By
Keith Alcorn
Lung Damage Poses New Hazard in HIV

In an observational study, people with uncontrolled HIV experienced a loss in lung function at a higher rate than HIV-negative people and those with good viral control.

Published
11 March 2012
From
MedPage Today HIV/AIDS
Progress, no big breakthrough, in hunt for HIV cure

Scientists, stymied for decades by the complexity of the human immunodeficiency virus, are making progress on several fronts in the search for a cure for HIV infections, a leading medical research conference was told this week.

Published
11 March 2012
From
Reuters
Scientists discover effects of PD-1 blockade on ART therapy in SIV-infected monkeys

Scientists have discovered that blocking PD-1, an immune molecule that inhibits the immune response to viral infections, can have a significant effect on HIV-like illness in non-human primates.

Published
11 March 2012
From
Science Daily
Circumcision reduces HIV incidence in Ugandan men and herpes prevalence in South Africans

The 19th Conference on Retroviruses and Opportunistic Infections (CROI) heard this week that a tenfold increase in medical male circumcision (MMC) in non-Muslim men in the Rakai district

Published
10 March 2012
By
Gus Cairns
Superinfection: second HIV infections happen as often as first ones

Two studies of people with HIV in Rakai, Uganda and Mombasa, Kenya presented at the 19th Conference on Retroviruses and Opportunistic Infections show that the rate at

Published
10 March 2012
By
Gus Cairns
Zolinza May Help Reduce Latent HIV Reservoirs In People With HIV (CROI 2012)

Results from a recent small study indicate that Zolinza, a drug currently approved to treat a certain type of lymphoma, may successfully reduce the size of the latent HIV reservoir in HIV-positive adults taking antiretrovirals.

Published
10 March 2012
From
The AIDS Beacon
Lopinavir Bests Nevirapine for HIV in Kids

For treating children infected with HIV, the protease inhibitor combination of lopinavir/ritonavir (Kaletra) outperforms the non-nucleoside reverse transcriptase inhibitor nevirapine (Viramune), researchers suggested here.

Published
09 March 2012
From
MedPage Today HIV/AIDS
Atherosclerosis Progression Halted By Metformin In HIV-Infected Patients

Treatment with the common diabetes drug metformin appears to prevent progression of coronary atherosclerosis in patients infected with HIV.

Published
09 March 2012
From
HIV / AIDS News From Medical News Today
UNAIDS welcomes further evidence of the positive impact of antiretroviral therapy on preventing new HIV infections

Researchers from the Africa Centre for Health and Population Studies have presented results which show that in areas where antiretroviral therapy uptake is high (greater than 30%) people who do not have HIV are 38% less likely to acquire the virus than in areas of low uptake (less than 10%).

Published
09 March 2012
From
UNAIDS

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