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Nucleotide analogue reverse transcriptase inhibitors (NtRTIs)
tenofovir
Names: tenofovir, Viread™
Approved dosage: One blue, almond shaped film-coated 300mg tablet daily. Dose may be adjusted if kidney function impaired.
Tips on taking it: take with food, to increase absorption. If you are also taking ddI, take tenofovir two hours before or one hour after ddI.
Common side-effects: diarrhoea, nausea.
Rare side-effects: longer-term side-effects of tenofovir are not yet established, however there are some reports of kidney toxicities. Creatinine monitoring advised to spot kidney damage, especially in patients with impaired kidney function.
Resistance to tenofovir: may cause resistance to ddI and ddC.
Key drug interactions: tenofovir increases levels of ddI.
TruvadaTM
Tenofovir is also available in a combined pill with the nucleoside analogue, FTC (emtricitabine). The tenofovir/FTC pill is called TruvadaTM. The dose is one blue tablet (300mg tenofovir and 200mg FTC) once a day.
Names: tenofovir, Viread™
Approved dosage: One blue, almond shaped film-coated 300mg tablet daily. Dose may be adjusted if kidney function impaired.
Tips on taking it: take with food, to increase absorption. If you are also taking ddI, take tenofovir two hours before or one hour after ddI.
Common side-effects: diarrhoea, nausea.
Rare side-effects: longer-term side-effects of tenofovir are not yet established, however there are some reports of kidney toxicities. Creatinine monitoring advised to spot kidney damage, especially in patients with impaired kidney function.
Resistance to tenofovir: may cause resistance to ddI and ddC.
Key drug interactions: tenofovir increases levels of ddI.
TruvadaTM
Tenofovir is also available in a combined pill with the nucleoside analogue, FTC (emtricitabine). The tenofovir/FTC pill is called TruvadaTM. The dose is one blue tablet (300mg tenofovir and 200mg FTC) once a day.