The standard dose of tenofovir (Viread) is one 200mg tablet once a day. Although taking tenofovir with food results in higher blood levels, this does not appear to affect the response to treatment. Labelling for tenofovir was amended in the United States in October 2003 to indicate that the drug does not have to be taken with food.

Patients who have difficulty taking tenofovir tablets can crush the pills and dissolve them in at least 100ml water, grape juice or orange juice.