Children
The recommended dose of indinavir (Crixivan) in children aged four to 17 years is 500mg/m2, up to a maximum of 800mg three times a day[1]. Indinavir has not been studied in children under four years of age.
As in adults, adequate hydration is important in children. Children weighing less than 20kg should drink at least 75ml/kg, and those over 20kg should drink at least 50ml/kg daily.
Several small studies of indinavir in HIV-infected children have been published, which suggest that indinavir has reasonable efficacy in children but causes kidney side-effects in up to a half of the children tested[2][3][4][5]. Younger children are especially prone to these side-effects, as are those with a family history of kidney stones.
Indinavir’s manufacturer has been attempting to develop a liquid suspension of indinavir for several years[6]. Currently, a lemon-flavoured syrup is being tested for use in children.
Ritonavir-boosted indinavir has been tested in 24 children, with four developing kidney side-effects. Adherence due to pill burden and palatability remained a key problem but the investigators managed to achieve appropriate drug levels[7].
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