d4T (stavudine, Zerit) is licensed for use in children over three months of age. The recommended dose is 1mg/kg twice daily in children weighing less than 30kg. Children above this weight should take the adult dose[1].

Studies have shown than the incidence of side-effects in children taking d4T is similar to that in adults.

Although unlicensed for use below three months, two studies have demonstrated that d4T-containing combinations are effective in very young infants:

  • With ddI (didanosine, Videx / VidexEC) and nelfinavir (Viracept), although this has a high rate of virological failure[2].
  • With 3TC (lamivudine, Epivir), nevirapine (Viramune) and nelfinavir: this combination can bring about viral suppression for up to four years in the majority of infants[3].