You may hear more about these drugs in the future; their use is still highly experimental in HIV infection.

Metformin

Keeps glucose levels down without stimulating insulin production. Also lowers cholesterol and triglyceride levels and may cause modest weight loss. Diarrhoea and nausea are common side-effects.

Sulphonylureas (glyburide, glipizide, gliclazide)

Stimulate insulin production so that blood glucose can be controlled.

Glitazones or TZDs

A new group of drugs that reduce the amount of insulin you need to control your blood sugar. Still experimental in HIV, and may interact with antiretrovirals. May also reduce central fat and increase sub-cutaneous fat.