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Patient Information Booklets
- What is a clinical trial?
- What sort of trials are carried out in HIV infection?
- What types of trial might I be asked to join?
- The different methods of comparing treatments
- The preparation for a trial
- Informed consent
- How to join a trial
- Reasons for and against joining a trial
- Questions to ask if you are thinking of joining a clinical trial
- Thinking it over
- Rights and responsibilities
- Summary
What sort of trials are carried out in HIV infection?
Clinical trials for people with HIV are currently testing treatments in six broad categories, at all stages of HIV disease. Some new trials are testing combinations of these approaches:
- Treatments intended to attack HIV at different stages of its lifecycle in order to stop or delay it damaging the immune system, such as protease inhibitors, non-nucleoside reverse transcriptase inhibitors (NNRTIs) or entry and integrase inhibitors in combination with other antiretroviral drugs.
- Treatments intended to improve the immune system (immunomodulators), such as interleukin-2.
- Treatments for side-effects, such as lipodystrophy.
- Treatments for other infections often seen in people with HIV such as hepatitis B virus or hepatitis C virus.
- Screening and treatment for sexually transmitted infections and anal and cervical cancer.
- Vaccines intended to stimulate an immune response to HIV or other infections.
