Many different therapies have been employed to alleviate the pain of peripheral neuropathy and reverse some of the nerve damage. While some of these have been shown to be effective in HIV-related neuropathy, many studies have failed to distinguish between neuropathy caused by HIV itself and neuropathy as a side-effect of anti-HIV drugs. In addition, many treatments have been tested in the similar condition seen in diabetics. Whether these results can be applied to HIV-positive patients is uncertain.