Loss of feeling or alteration in sensation (such as pins and needles) can occur in HIV infection especially in the toes, feet and hands. Altered sensation with numbness can cause burning pain.

Causes

HIV and some secondary infections of the brain, spinal cord and nerve roots (e.g. CMV) can cause inflammation of the peripheral nerves (peripheral neuropathy). Drugs (such as ddC and cancer chemotherapy regimens), vitamin deficiencies and alcohol can also be responsible.

If numbness in the feet is accompanied by pins and needles or more severe pain when pressure is exerted, this may be peripheral neuropathy. See A to Z of illnesses: Neuropathy.

What to do

These symptoms should be discussed with your doctor and the underlying cause established. Amitriptylline in low doses or carbamazepine may be helpful for the burning pain. Practical measures such as taking good care of your feet, wearing good fitting shoes or seeing a chiropodist are also important. See A to Z of illnesses: Neuropathy for further information.