SID791 is an experimental drug that belongs to a new class of compounds known as bicyclams. In the test-tube, it appears to prevent HIV from infecting human cells, either by preventing the virus gp120 molecule from fusing with the cells CD4 molecule, or by preventing the release of the virus genetic material into the cell after it has fused.

SID791 is also known as JM3100, and was being developed by Sandoz. No further data on this compund has been reported since 1996.

References

Bridger GJ et al. Synthesis and structure-activity relationships of phenylenebis-(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker. J Med Chem 38:366-378, 1995.

De Vreese K. et al. The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication. J Virology 70:689-696, 1996.

DeClercq E et al. Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100. Antimicrobial Agents and Chemotherapy 38:668-674, 1994.