Drug-resistant TB

Drug-resistant TB features

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  Managing MDR-TB in the community: from presentation to cure or end-of-life care

  Part of a series, this edition examines the sequence of care of a person with drug-resistant TB. ...

  From:HIV & AIDS treatment in practice

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  Decentralised, patient-centred models of delivering treatment and palliative care for people with M/XDR-TB

  Part of a series on improving care of multidrug-resistant tuberculosis, this edition examines delivery of treatment and palliative care, focusing on decentralised patient-centred TB care....

  From:HIV & AIDS treatment in practice

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  Towards more compassionate and effective care for drug resistant TB: improving diagnosis and case detection

  The second in a series of articles on improving care for people with multidrug-resistant tuberculosis, this edition of HATIP focuses on detection and diagnosis....

  From:HIV & AIDS treatment in practice

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  Towards more compassionate care for people with drug-resistant TB

  Review of the epidemiology, prognosis and complications of multi-drug (MDR) and extensively drug-resistant (XDR) TB in people with HIV....

  From:HIV & AIDS treatment in practice

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  HIV and TB in Practice

  This articles looks at the issue of isoniazid resistance in isoniazid preventive therapy (IPT) and TB programmes. ...

  From:HIV & AIDS treatment in practice

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  Childhood TB (part 3): treatment and prevention

  This is the third part of Childhood TB covering treatment and prevention including antiretroviral treatment for children co-infected. ...

  From:HIV & AIDS treatment in practice

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  Scaling up laboratory capacity for the coming storm of XDR-TB, and why the HIV treating community must get involved now

  Review of issues in monitoring TB drug sensitivity in resource-limited settings, and the need to scale up laboratory capacity in order to detect MDR and...

  From:HIV & AIDS treatment in practice

Drug-resistant TB news from aidsmap

• Poor adherence not enough to cause development of MDR-TB

  Poor adherence may not be enough to cause multidrug-resistant tuberculosis, a laboratory study published in the online edition of the Journal of Infectious Diseases suggests. Moreover, the failure of tuberculosis (TB) therapy only occurred at extremely high levels of non-adherence. ...

  08 November 2011 | Michael Carter

• Funding for TB research and development declining

  Funding levels for tuberculosis (TB) research and development (R &D) fell by 0.3% in 2010 compared to 2009, according to new data released by the Treatment Action Group (TAG) and the Stop TB Partnership in the annual Report on ...

  07 November 2011 | Lesley Odendal

• Interruption of TB treatment due to drug supply problems common in UK

  A quarter of United Kingdom hospitals providing TB treatment had to interrupt a course of treatment due to drug supply problems in 2007 and 2008, according to results of a survey published this month in the International Journal of ...

  18 May 2011 | Keith Alcorn

• Private sector TB treatment in Asia: a lot of it, but often sub-optimal

  Private sector markets for tuberculosis drugs in some Asian countries are providing enough drugs to treat every new TB case each year – but in many cases patients appear to be receiving drug regimens that are not recommended in ...

  06 May 2011 | Keith Alcorn

• Vigilance needed over MDR-TB in children, South African doctors warn

  South African doctors have found a high prevalence of multi-drug resistant tuberculosis among children receiving care in a Johannesburg hospital, highlighting the need to screen for drug resistance and test for HIV in children with TB symptoms. Among a cohort of children ...

  04 February 2011 | Carole Leach-Lemens

• Patients taking TB treatment may be potentially infectious for longer than previously thought

  Patients taking directly observed therapy (DOTS) for tuberculosis (TB) may be potentially infectious for longer than previously thought, investigators report in the August 15th edition of Clinical Infectious Diseases. Moreover, the researchers found that many patients were TB culture-positive ...

  10 August 2010 | Michael Carter

• Household contact tracing reveals extensive community spread of MDR and XDR TB

  Approximately half of adult household contacts of drug resistant TB cases had resistance profiles that differed from the index case of TB, according to a presentation given by Dr. Tony Moll at the 40th Union World ...

  08 January 2010 | Lois Eldred

• XDR TB emerging despite good adherence, due to sub-optimal treatment and bad infection control

  Extensively drug-resistant tuberculosis is most likely emerging as a result of delays in diagnosis, sub-optimal treatment and poor infection control, not failures in patient adherence, a newly published study of XDR TB cases in a South ...

  10 February 2010 | Keith Alcorn

• High prevalence of drug-resistant TB amongst HIV patients in South Africa

  There is a high prevalence of multidrug-resistant tuberculosis amongst patients with HIV in South Africa, investigators report in the April 1st edition of Clinical Infectious Diseases. Overall, almost 20% of HIV-positive patients with TB in a cohort ...

  17 March 2010 | Michael Carter

• Over a third of TB cases in UK prisons are drug-resistant

  Many UK prisoners with tuberculosis have a drug-resistant form of the disease, according to a study published in the Journal of Epidemiology and Community Health. The research also showed that the majority of tuberculosis (TB) cases ...

  18 March 2010 | Michael Carter

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Drug-resistant TB news selected from other sources

• Fear-Resistance: How Worried Should We Be about "Totally Drug-Resistant" Tuberculosis?

  An Indian clinic's claim of totally untreatable TB ignited public fears, but experts say poor disease management is the real threat

  01 February 2012 | Scientific American

• Patient with deadly TB strain tests positive for HIV

  A patient with extra-extremely drug-resistant tuberculosis (XXDR TB) has tested positive for HIV. Public health experts say the coming together of the two dreaded infections is worrying.

  26 January 2012 | Times of India

• Indian TB cases 'can't be cured'

  Tuberculosis which appears to be totally resistant to antibiotic treatment has been reported for the first time by Indian doctors.

  17 January 2012 | BBC Health

• Totally Drug Resistant TB strain turns up in patients in India

  Doctors at the Hinduja National Hospital and Research Centre in Mumbai, India, are reporting on a strain of tuberculosis (TB) emerging among patients that is resistant to all first- and second-line drugs used to treat the bacterial infection. At least twelve patients have been identified so far.

  11 January 2012 | Science Speaks: HIV & TB News

• Deadly tuberculosis stalks Europe

  The WHO's Regional Office for Europe recently released a report that warned about the spread of the hard-to-treat MDR-TB into all of Europe, making the case that the relatively wealthy capitals of the West faced the grave danger of a much higher number of cases if the entire region did not move quickly to put in place effective control measures.

  03 January 2012 | Global Post

• New Six-Way Agreement Among Pharmas and NGOs will Speed Development of TB Drug Combinations

  The Critical Path to TB Drug Regimens (CPTR) today announced an innovative agreement between AstraZeneca, Bayer, Sanofi, Tibotec, TB Alliance, and the World Health Organization to share information on tuberculosis (TB) compounds within their respective drug pipelines to quickly identify and work together to develop the most promising TB drug regimen, regardless of sponsor.

  10 November 2011 | Critical Path to TB Drug Regimens

• WHO and PATH publish toolkit on strategies to address MDR-TB

  WHO and PATH have published a toolkit designed to help countries develop or strengthen the multidrug-resistant tuberculosis (MDR-TB) components within national TB strategies or plans.

  06 October 2011 | Stop TB Partnership

• TB & me: Real stories of people living with multidrug-resistant tuberculosis

  Phumeza, from Khayelitsha in South Africa, decsribes her experience of MDR treatment.

  16 September 2011 | MSF

• Plan to tackle drug-resistant TB

  A plan has been drawn up to try to tackle the problem of drug-resistant tuberculosis in 53 European countries.

  14 September 2011 | BBC Health

• SOUTH AFRICA: Shortage of drug-resistant TB treatment looms

  While countries are rolling out new tests that will enable them to diagnose more patients with drug-resistant tuberculosis (DR-TB), a worldwide shortage of the drugs to treat these patients is likely, Médecins Sans Frontières (MSF) warns.

  22 August 2011 | IRIN Plus News

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