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  • ART use not linked to advanced kidney disease in 35,000 with HIV

    Neither current nor recent use of tenofovir or any other antiretroviral therapy (ART) predicted advanced chronic kidney disease (CKD) or end-stage renal disease (ESRD) in a study or more than 35,000 adults with HIV infection.

    12 February 2014 | International AIDS Society
  • What ‘Dallas Buyers Club’ got wrong about the AIDS crisis

    'Tis the season for Oscar bait, and this year, "Dallas Buyers Club" looks set to get at least a few nominations. The movie stars Matthew McConaughey as Ron Woodroof, a Dallas man who contracts HIV in 1985, when the diagnosis was a death sentence. But it risks leaving a false impression of that period in the history of HIV/AIDS, and in particular of the role of AZT.

    11 December 2013 | Washington Post
  • Unusual and rare complication described in San Francisco

    Doctors in San Francisco have reported an unusual and rare finding—an apparently harmless but disfiguring condition called cutis verticis gyrata (CVG) on the heads of four HIV-positive men. In CVG, the skin on the head becomes raised in parts and depressed in others, forming ridges and furrows.

    09 December 2013 | CATIE
  • Differing Effects of Low- and High-Fat Meals on New Raltegravir Formulation

    A high-fat meal affected levels of a reformulated raltegravir tablet less than a low-fat meal, according to results of a three-period study in healthy volunteers [1]. One aim of this trial and other ongoing research is to develop a raltegravir formulation that can be dosed once daily.

    30 October 2013 | NATAP
  • Crofelemer effective for severe or PI-related diarrhea in placebo trial

    Crofelemer, a botanically derived agent indicated for symptomatic relief of noninfectious diarrhea in antiretroviral-treated people, proved particularly effective against severe, intransigent diarrhea and protease inhibitor (PI)-related diarrhea in subgroup analyses of a double-blind placebo-controlled trial.

    19 September 2013 | NATAP
  • Switching From Efavirenz to Rilpivirine Combo Quells CNS Side Effects

    Swapping efavirenz-containing Atripla for rilpivirine-containing Complera (Eviplera in Europe) significantly lowered rates of central nervous system (CNS) side effects and sleep disturbances in a 40-person multicenter pilot trial.

    13 September 2013 | NATAP
  • Ketamine use linked to liver and other problems in HIV-positive people

    Case reports suggest that HIV treatment may exacerbate liver damage and other health problems caused by the use of ketamine - a veterinary drug increasingly used as a recreational 'party' drug.

    07 August 2013 | CATIE
  • Methadone arrhythmia rate rising in US, ART may pose higher risk

    Rates of cardiac arrhythmias associated with methadone rose in the United States from 1997 to 2011, according to analysis of the US Food and Drug Administration Adverse Event Reporting System (FAERS). Taking methadone with antiretroviral therapy (ART) may pose a particular risk.

    15 July 2013 | International AIDS Society
  • Low-Dose Drug Combo Safe in Kids with HIV

    A low-dose treatment regimen with lopinavir/ritonavir antiretroviral therapy appears to have similar efficacy with fewer adverse events than standard dosing in HIV-infected children, researchers said at the 7th IAS Conference on HIV Pathogenesis, Treatment and Prevention in Kuala Lumpur.

    08 July 2013 |
  • Am I mad or is it the meds?

    It’s 00:50 and once again I can’t sleep. My insomnia has kept me up for the best part of three days in a row now, my mind is tired, my body is exhausted and yet I still can’t sleep.

    07 June 2013 | UK Positive Lad (blog)
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