Resistance

Resistance in your own words

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  My life with HIV

  I was born in Zambia in 1973 and came to England in April 1994 to live with my cousin to help her look after her...

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Resistance news from aidsmap

• HIV treatment breaks lead to drug resistance in the female genital tract

  Antiretroviral treatment interruptions of 48 hours or more are associated with the emergence of resistant strains of HIV in the female genital tract, investigators report in the online edition of the Journal of Acquired Immune Deficiency Syndromes. The study ...

  19 hours ago | Michael Carter

• Superinfection: second HIV infections happen as often as first ones

  Two studies of people with HIV in Rakai, Uganda and Mombasa, Kenya presented at the 19th Conference on Retroviruses and Opportunistic Infections show that the rate at which they acquired second, subsequent strains of HIV was about the same ...

  10 March 2012 | Gus Cairns

• Second-line treatment failure most often due to poor adherence in low and middle-income countries

  Poor adherence rather than drug resistance appears more likely to be the cause of virological failure among patients on second-line ART in resource-poor settings, according to a systematic review and meta-analysis published in the advance online edition of AIDS. The cumulative ...

  24 February 2012 | Carole Leach-Lemens

• Drug combinations pairing AZT and efavirenz have highest resistance risk

  HIV treatment regimens that include both efavirenz and AZT have the highest rates of resistance, according to Swiss research published in the online edition of Clinical Infectious Diseases. The findings underline the greater durability of antiretroviral drug combinations that ...

  08 November 2011 | Michael Carter

• 'High viral load' should mean over half a million copies, not over 100,000, Rome study suggests

  A study by the University of Rome has found that a substantial proportion of patients with HIV are being diagnosed with viral loads of over half a million copies/ml, and it is these patients who are at raised risk ...

  24 October 2011 | Gus Cairns

• Global survey shows high frequency of resistance after first-line ART failure in children

  90% of HIV-infected children in the resource-poor regions of Africa, Asia and Latin America had at least one drug resistance mutation after failure of first-line ART, Dutch researchers report in a systematic review published in this month’s Lancet Infectious ...

  06 October 2011 | Carole Leach-Lemens

• Big falls in prevalence of protease inhibitor and triple-class resistance

  The prevalence of HIV resistance to protease inhibitors fell sharply between 2003 and 2010, according to a study presented to the 51st ICAAC meeting in Chicago. Investigators from Monogram Biosciences analysed the profile of almost 70,000 stored blood samples ...

  19 September 2011 | Michael Carter

• Low but detectable viral load during HIV treatment involves a risk of resistance

  Drug resistance frequently develops in patients who have a persistent low detectable viral load when taking HIV therapy, US investigators report in the August 15th edition of the Journal of Infectious Diseases. Treatment guidelines which set the bar ...

  02 August 2011 | Michael Carter

• Viral load monitoring of ART patients linked to lower death rate on treatment in southern Africa

  After three years on ART patients enrolled in four scale-up programmes with routine viral load monitoring in South Africa had a fifty percent lower death rate than patients in two public sector programmes in Malawi and Zambia where monitoring is ...

  14 July 2011 | Carole Leach-Lemens

• One in eight European children with HIV experienced failure of three drug classes within five years

  One in eight children and adolescents receiving HIV treatment at major HIV clinics in Europe experienced failure of three classes of antiretroviral drugs after five years of treatment, highlighting the need for formulations of new antiretroviral drugs to be developed ...

  26 April 2011 | Carole Leach-Lemens

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Resistance news selected from other sources

• UGANDA: Rising ARV resistance threatens HIV fight

  The prevalence of drug-resistant HIV strains in Uganda has risen from 8.6 percent to 12 percent in the last five years, one of the highest rates in Sub-Saharan Africa, according to a recent study.

  22 May 2012 | IRIN Plus News

• Transmitted HIV Drug Resistance on the Rise in U.S.

  New surveillance data from the U.S. Centers for Disease Control and Prevention (CDC) suggest that about two in 10 individuals diagnosed with HIV in recent years were infected with HIV strains harboing mutations conferring at least partial resistance to one ore more available antiretroviral (ARV). The report was presented Wednesday, March 7, at the 19th Conference on Retroviruses and Opportunistic Infections in Seattle.

  21 March 2012 | AIDSMeds

• UCLA researchers suggest unconventional approach to control HIV epidemics

  Because PrEP is based on the same drugs used to treat HIV-infected individuals, the big public health scare is that the dual use of these drugs will lead to skyrocketing levels of drug resistance. In fact, say UCLA researchers in a new study, that is not the case and indeed, the exact opposite is likely to happen.

  07 December 2011 | Eurekalert Medicine & Health

• Microsoft Research: Spammers Act Just Like HIV Virus In Avoiding Filters

  Security researchers often use language and metaphors from the natural world to describe problems in the virtual world. (Thus, our use of the terms "virus," and "worm.") Now it turns out that the links may not be so arbitrary, after Microsoft researchers discovered that tools they developed to detect spammers' efforts to avoid anti-spam filters were also great at spotting mutations in the HIV virus.

  03 December 2011 | ThreatPost.com

• Children with HIV in Asia suffer resistance to AIDS drugs

  eenagers in Asia receiving treatment for HIV are showing early signs of osteoporosis and children as young as five are becoming resistant to AIDS drugs, an anti-AIDS group said on Thursday, urging more attention be given to young HIV patients.

  01 December 2011 | Reuters

• HIV Drug Resistance Effect Damped Down over Time

  The proportion of HIV patients who are able to suppress the virus despite extensive drug resistance nearly tripled over a 10-year period, researchers reported.

  10 October 2011 | MedPage Today

• Zimbabwe: Drug-Resistant HIV Strain Noted

  Four cases of an HIV strain resistant to first line treatment have been reported at Father O'hea Hospital in Zvimba and were confirmed by tests conducted in Uganda recently.

  24 August 2011 | AllAfrica

• Israeli study may point to the future of the HIV epidemic in men who have sex with men

  Over the past decade across high-income countries an unexpected and disturbing trend has emerged—an increase in syphilis and HIV infections among men who have sex with men (MSM). Now researchers in Israel have found similar trends in HIV in that country. Furthermore, researchers there have found that about 30% of MSM newly infected with HIV have strains that are resistant to some anti-HIV therapies.

  31 May 2011 | CATIE

• Is there a future for HIV-infected patients in deep salvage?

  Most of us built resistance as we joined study after study that exposed us to functional monotherapy. In fact, I consider many of us who have been struggling with multiple drug resistance to be wounded soldiers from a time when we were recruited into studies we joined out of desperation to access a new drug.

  04 May 2011 | The Body

• HIV study claims one in eight children resistant to drugs

  One in eight children born with HIV becomes resistant to the three main classes of drugs used to suppress the virus within five years of starting treatment.

  20 April 2011 | The Guardian

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