Younger injecting drug users and gay men optimistic about HAART likely to have safer sex fatigue

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Younger injecting drug users and gay men who are optimistic about the success of HAART are more likely to express fatigue with HIV prevention messages, according to a study conducted in San Francisco and published in the April 1st edition of the Journal of Acquired Immune Deficiency Syndromes. "Prevention fatigue" was not associated with a greater likelihood of unprotected sex, but was associated with greater sharing of drug injecting equipment.

Investigators analysed responses provided by 303 HIV-negative individuals at high risk of HIV who participated in the anonymous 2001 HIV Testing Survey (HITS). The study sample included 105 gay men recruited from gay bars, 99 heterosexuals recruited from public sexual health clinics, and 99 injecting drug users who were recruited from street locations in areas known to be associated with drug use.

Participants were asked how strongly they agreed or disagreed with six questions relating to their beliefs about HIV. Their answers were then graded to assess their HIV prevention fatigue. The maximum possible score, indicating a high degree of prevention fatigue, was 3.67, and the minimum score 1.00.

Glossary

fatigue

Tiredness, often severe (exhaustion).

 

p-value

The result of a statistical test which tells us whether the results of a study are likely to be due to chance and would not be confirmed if the study was repeated. All p-values are between 0 and 1; the most reliable studies have p-values very close to 0. A p-value of 0.001 means that there is a 1 in 1000 probability that the results are due to chance and do not reflect a real difference. A p-value of 0.05 means there is a 1 in 20 probability that the results are due to chance. When a p-value is 0.05 or below, the result is considered to be ‘statistically significant’. Confidence intervals give similar information to p-values but are easier to interpret. 

sample

Studies aim to give information that will be applicable to a large group of people (e.g. adults with diagnosed HIV in the UK). Because it is impractical to conduct a study with such a large group, only a sub-group (a sample) takes part in a study. This isn’t a problem as long as the characteristics of the sample are similar to those of the wider group (e.g. in terms of age, gender, CD4 count and years since diagnosis).

safer sex

Sex in which the risk of HIV and STI transmission is reduced or is minimal. Describing this as ‘safer’ rather than ‘safe’ sex reflects the fact that some safer sex practices do not completely eliminate transmission risks. In the past, ‘safer sex’ primarily referred to the use of condoms during penetrative sex, as well as being sexual in non-penetrative ways. Modern definitions should also include the use of PrEP and the HIV-positive partner having an undetectable viral load. However, some people do continue to use the term as a synonym for condom use.

Across all the risk groups, the mean score was 2.02. Although there were no significant differences according to race, gender or monthly income, individuals with less than a college education were more likely to express prevention fatigue (p=0.022).

To assess if individuals had prevention fatigue, they were asked if they were "burned out thinking about HIV", if they were "tired or being safe", if they had stopped listening to HIV prevention messages, if they didn't want to hear anymore about HIV, if they were "tired of being careful" and if they thought HIV was "somebody else's" problem.

The level of prevention fatigue also varied between and within risk groups. Injecting drug users had a higher level of fatigue than heterosexuals (p<0.001), and injecting drug users under 25 expressed more fatigue than older injecting drug users (p=0.012).

Although prevention fatigue was not associated with unprotected anal sex between gay men or unprotected vaginal sex in heterosexuals, the investigators did find that injecting drug users expressing prevention fatigue were more likely to share injecting equipment (p=0.020).

Further, the investigators found that gay men expressing optimism about HAART were more likely to score highly on the prevention fatigue scale (p<0.001).

The investigators conclude, “our data suggest that prevention fatigue may be a concern for certain populations at risk of acquiring HIV… or transmitting HIV to others.”

Further information on this website

Safer sex fatigue and HAART optimism explain rise in US bareback sex - news story

References

Stockman JK et al. HIV prevention fatigue among high-risk populations in San Francisco. JAIDS 35: 432 – 433, 2004.