Vaccines

Vaccines features

• Low levels of innate immune activation and high levels of gut antibodies may protect people from HIV

  Several research papers published in the last month have reported strong correlations between specific immune responses and protection against HIV infection or its effects. These include...

  From:  News

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  What about a vaccine?

  There are two ultimate solutions to HIV: a cure and a vaccine. We cover research towards a cure in this issue. But how is the search for...

  From:  HIV treatment update

• 

  Can we create ‘elite controllers’?

  Is combination immunotherapy the future? ask Edwin J Bernard and Derek Thaczuk ...

  From:  HIV treatment update

Vaccines news from aidsmap

• Gene therapy studies show potential for HIV control without drugs

  Gene therapy approaches that involve the genetic modification of human haematopoietic stem cells have the potental to engineer HIV control by introducing cells resistant to HIV infection, the 20th Conference on Retroviruses and Opportunistic Infections ...

  13 March 2013 | Gus Cairns

• Low levels of innate immune activation and high levels of gut antibodies may protect people from HIV

  Several research papers published in the last month have reported strong correlations between specific immune responses and protection against HIV infection or its effects. These include a comparison of women in the CAPRISA 004 microbicide trial who became infected and ...

  24 August 2012 | Gus Cairns

• Lower seminal viral load and hints of long-term viral control seen in Thai HIV vaccine recipients

  Men who received the Thai RV144 vaccine who nonetheless became infected with HIV had lower viral loads in their semen than men who received placebo, a new analysis of the vaccine study reports in the Journal of Infectious Diseases.    The report ...

  17 August 2012 | Gus Cairns

• BCG vaccination causes immune activation of CD4 T-cells in infants

  BCG vaccination, routinely given at birth to protect from tuberculosis (TB), causes an immune-activation of CD4 T cells, the HIV target cells, according to a South African study presented at the Nineteenth International AIDS Conference in Washington DC. This immune ...

  31 July 2012 | Lesley Odendal

• Superinfection: second HIV infections happen as often as first ones

  Two studies of people with HIV in Rakai, Uganda and Mombasa, Kenya presented at the 19th Conference on Retroviruses and Opportunistic Infections show that the rate at which they acquired second, subsequent strains of HIV was about the same ...

  10 March 2012 | Gus Cairns

• US CDC recommends HPV vaccine for young men

  Young men and adolescent boys between the ages of 11 and 21 should be vaccinated against human papillomavirus, the cause of genital warts, anal and cervical cancer, the Advisory Committee on Immunization Practices has recommended, in a new Adult ...

  06 February 2012 | Keith Alcorn

• Vaccine provides strong protection against HIV-like infection in monkeys

  A new vaccine approach provided monkeys with a high level of protection against a virulent form of SIV, the monkey equivalent of HIV. Vaccine researchers say the findings are promising, and provide important pointers on how to design an ...

  06 January 2012 | Keith Alcorn

• New vaccine against pneumococcal disease approved for UK

  A new vaccine that may be more suitable for preventing pneumococcal disease in people living with HIV has been approved in the United Kingdom. Prevenar 13, manufactured by Pfizer, is targeted at 13 variants of Streptococcus pneumoniae. Recently published research ...

  30 November 2011 | Keith Alcorn

• Immunisation doesn't prevent mother-to-child HIV transmissions, but approach should not be abandoned, says expert

  An experimental immunisation does not confer any addition protection against mother-to-child transmission of HIV compared to single-dose nevirapine, investigators report in the December 1st edition of the Journal of Acquired Immune Deficiency Syndromes.    The phase III, randomised study was conducted ...

  15 November 2011 | Michael Carter

• HIV vaccine technologists edge nearer to effective designs

  A vaccine symposium held at the sixth International AIDS Society conference (IAS 2011) in Rome heard how designers are slowly developing HIV vaccines designed to overcome problems that had prevented the creation of an effective vaccine in the ...

  22 July 2011 | Gus Cairns

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Vaccines news selected from other sources

• Injection-free vaccination technique could address global vaccine challenge for diseases such as HIV and malaria

  Scientists at King’s College London have demonstrated the ability to deliver a dried live vaccine to the skin without a traditional needle, and shown for the first time that this technique is powerful enough to enable specialised immune cells in the skin to kick-start the immunising properties of the vaccine.

  11 February 2013 | Kings College London press release

• Vaccine group funds cervical cancer immunizations for poor

  The GAVI global vaccines group is to help protect more than 180,000 girls in eight countries across Africa and Asia from cervical cancer by funding immunization projects with vaccines from Merck and GlaxoSmithKline.

  04 February 2013 | Reuters

• New insights into HIV vaccine will improve drug development

  Four years ago, a potential HIV vaccine showed promise against the virus that causes AIDS, but it fell short of providing the broad protection necessary to stem the spread of disease. Now researchers -- led by Duke Medicine -- have gained additional insights into the workings of the vaccine that help explain why it benefited a third of recipients and left others vulnerable.

  11 January 2013 | Science Daily

• Crowdfunding an HIV Vaccine: Insane or Genius?

  Under the guidance of my board at the Abzyme Research Foundation I launched a crowd-fund to start a new therapeutic vaccine on the FDA approval process on Dec. 1 In two weeks we have raised 50 percent of our initial goal and I believe the project is attractive to donors for two reasons.

  21 December 2012 | Huffington Post (blog)

• Major Breakthrough in HIV Research: Swiss Vaccine Research Institute

  A study published today online in The Journal of Experimental Medicine has identified the population of CD4 T cells serving as the major reservoir for HIV infected cells and as the primary cell site for HIV replication and production in infected patients. The identification of the major HIV CD4 T cell reservoir will be instrumental in developing therapeutic strategies to selectively target HIV infected cells.

  18 December 2012 | Business Wire

• THERAVECTYS is granted authorization from the French and Belgian regulatory agencies to launch a Phase III clinical trial for its anti-HIV therapeutic vaccine candidate

  The world’s first use of lentiviral vector technology in the vaccine field .

  04 December 2012 | EATG

• Texas Biomed files patent for a novel HIV vaccine strategy

  The Texas Biomedical Research Institute in San Antonio has applied for a patent for a genetically-engineered vaccine strategy to prevent HIV infection that targets the outer layers of body structures that are the first sites of contact with the virus.

  20 November 2012 | Medical Xpress

• SOUTH AFRICA: Two women unlock possible key to HIV vaccine

  Two South African women may have helped unlock the key to a vaccine to rid the world of one its deadliest epidemics, according to new research released by South African HIV experts. Because they acquired HIV while taking part in large-scale clinical trials, researchers were able to follow them for years, discovering in the process that their bodies produce rare antibodies found in only one out of every five HIV patients.

  23 October 2012 | IRIN Plus News

• SA antibody breakthrough ‘brings HIV vaccine closer’

  SouthAfrican scientists have discovered how some people can make potent antibodies capable of neutralising strains of HIV, taking researchers a step closer to developing a vaccine.

  23 October 2012 | Business Day

• HPV vaccination does not lead to an increase in sex

  A study published in Vaccine reveals that contrary to recent discussions, the HPV vaccination does not increase sexual activity in adolescent girls.

  11 October 2012 | Eurekalert Medicine & Health

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