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  • START Making Sense

    The story of the START trial will continue to be told for a long time to come. For some it will be a tale of rigorous perseverance in the face of strong counter-prevailing headwinds and ultimate arrival at a result that is solid and conclusive. Others will see a single-minded and aggressive defense of a trial by investigators who refused to accept not only the obvious but also the evidence that rendered their design obsolete and even unethical.

    19 June 2015 | North Carolina AIDS Training and Education Center
  • When to START has never been clearer

    Posirtive Lite editor Bob Leahy in conversation with CATIE’s Sean Hosein about START, the important and ground-breaking study that recently provided definitive evidence of the health benefits of starting HIV treatment sooner rather than later.

    10 June 2015 | Positive Lite
  • Early HIV Treatment Is Essential, But So Is Testing And Linkage To Care

    Last week’s announcement of the Strategic Timing of AntiRetroviral Treatment (START) trial results confirms what many experts have long believed — early treatment for HIV reduces illness and death. While START further establishes the vital role of early antiretroviral therapy (ART), many questions remain on how to actually bring the life-saving benefits of treatment to individual patients.

    05 June 2015 | Health Affairs (blog)
  • New START Data Fill in When to Start ART, Now the Question is How

    It's critical to recognize that figuring out when to start is only part of the puzzle. The question of how to start is equally critical and isn’t going to be settled by any randomized trial. The how concerns the environment in which individuals are offered treatment, the services that are part of that offer—peer support, community-based refills, non-biased provider care, among others—and the ways that the decision to start is framed.

    29 May 2015 | AVAC
  • START findings highlight treatment divide

    The START data show that basing treatment initiation on immune cell count is a form of rationing. But whether, how soon, and even how the findings will change clinical practice is another question.

    28 May 2015 | Science Speaks
  • UNAIDS welcomes further evidence that starting antiretroviral therapy early saves lives

    “Every person living with HIV should have immediate access to life-saving antiretroviral therapy,” said Michel Sidibé, Executive Director of UNAIDS. “Delaying access to HIV treatment under any pretext is denying the right to health.”

    28 May 2015 | UNAIDS
  • i-Base Q&A on the START study results

    On 27 May 2015, early results showed that the early treatment group did better. One of the surprises is that even at very high CD4 counts, treatment reduces the risk of HIV related illnesses.

    28 May 2015 | HIV i-Base
  • US guidelines shift to integrase-based combinations for first-line treatment: Atripla relegated due to side effects

    The rationale for dropping Atripla is due to concerns about the tolerability of efavirenz, especially the high rate of central nervous system related toxicities. Although this has been a long-standing community concern, DHHS guidelines have consistently recommended efavirenz in previous editions. This tolerability statement is made in the year that efavirenz comes off patent.

    06 May 2015 | i-Base
  • HIV Treatment Guidelines Nix Atripla as First-Line Therapy

    A revision of U.S. HIV treatment guidelines has removed Atripla (efavirenz/tenofovir/emtricitabine) from the priority list of first-line antiretrovirals.

    09 April 2015 | AIDSMeds
  • WHO issues its first hepatitis B treatment guidelines

    WHO today issued its first-ever guidance for the treatment of chronic hepatitis B, a viral infection which is spread through blood and body fluids, attacking the liver and resulting in an estimated 650 000 deaths each year – most of them in low- and middle-income countries.

    12 March 2015 | World Health Organization
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