The search for a cure

The search for a cure features

• Low levels of innate immune activation and high levels of gut antibodies may protect people from HIV

  Several research papers published in the last month have reported strong correlations between specific immune responses and protection against HIV infection or its effects. These include...

  From:  News

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  Eliminating HIV: latest progress

  At the 19th Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle last month there were three main areas of discussion. Prevention and hepatitis C (which we...

  From:  HIV treatment update

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  HIV gene therapy

  In April’s HTU, we featured a news story, reporting that a group of patients had had their CD4 counts boosted by a form of gene therapy – and...

  From:  HIV treatment update

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  Towards a cure for all: How we might do it

  In the second part of this two-part feature, Gus Cairns investigates current research into finding a cure for HIV....

  From:  HIV treatment update

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  Towards a cure for all (part one)

  For the first time, someone has been cured of HIV infection. It was a brutal and expensive procedure but, as Gus Cairns reports, in the first of a...

  From:  HIV treatment update

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  The cure

  Could we eliminate HIV from the body altogether? Keith Alcorn looks at the latest milestones in a long journey of discovery. ...

  From:  HIV treatment update

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  A ‘functional cure’?

  Examining the excitement over a bone marrow transplant that ‘eradicated’ HIV, by Edwin J Bernard. ...

  From:  HIV treatment update

The search for a cure news from aidsmap

• French researchers report 14 patients in 'remission' after controlling HIV for over 4 years off treatment

  Two weeks ago, the announcement that a baby had been ‘functionally cured’ of HIV disease with the use of very early antiretroviral therapy (ART) caused great excitement at the start of the Conference on Retroviruses and Opportunistic Infections (CROI 2013). ...

  16 March 2013 | Gus Cairns

• Gene therapy studies show potential for HIV control without drugs

  Gene therapy approaches that involve the genetic modification of human haematopoietic stem cells have the potental to engineer HIV control by introducing cells resistant to HIV infection, the 20th Conference on Retroviruses and Opportunistic Infections ...

  13 March 2013 | Gus Cairns

• Very early antiretroviral treatment limits the size of HIV reservoir

  Very early antiretroviral treatment may limit the size of the HIV reservoir in adults and children, according to studies presented on 4 March at the 20th Conference on Retroviruses and Opportunistic Infections (CROI) in Atlanta. Other research presented at ...

  05 March 2013 | Keith Alcorn

• Case report of a 'functional' HIV cure in a child

  Researchers in the United States say that they have identified a case of a 'functional' HIV cure in a child infected with HIV who began antiretroviral treatment within days of birth. The child has now been off treatment for ...

  03 March 2013 | Keith Alcorn

• CMV infection may contribute to the size of the latent HIV reservoir

  The presence of cytomegalovirus (CMV) in blood and semen is associated with higher levels of HIV DNA in blood, investigators from the United States report in the online edition of Journal of Infectious Diseases. The study involved gay men ...

  16 January 2013 | Michael Carter

• Low levels of innate immune activation and high levels of gut antibodies may protect people from HIV

  Several research papers published in the last month have reported strong correlations between specific immune responses and protection against HIV infection or its effects. These include a comparison of women in the CAPRISA 004 microbicide trial who became infected and ...

  24 August 2012 | Gus Cairns

• Latest data on HIV cure research

  Investigators presented some of the latest HIV cure-related research at a press conference and oral session on viral reservoirs at the 19th International AIDS Conference (AIDS 2012) this week in Washington, DC. Experts also met for a two-day ...

  27 July 2012 | Liz Highleyman

• What do people living with HIV think about the prospect of a cure?

  The views of people living with HIV and medical researchers about what makes an HIV cure desirable may be very different, and need to be taken into account as the field of HIV cure research moves forward, Fred Verdult ...

  22 July 2012 | Keith Alcorn

• Researchers step up efforts to find an HIV cure

  Scientists launched a road map for research into an HIV cure ahead of the 19th International AIDS Conference (AIDS 2012) in Washington DC, promising international collaboration and calling for more funding to be devoted to research that can eventually ...

  22 July 2012 | Keith Alcorn

• Four-class, five-drug regimen given to monkeys shows signs of producing long-term viral load reductions off treatment

  An animal study (Shytaj) in which standard antiretroviral therapy (ART) was intensified by adding in drugs from other classes has shown signs that it may be possible, using antiretroviral drugs (ARVs) alone, to produce a permanent reduction ...

  29 June 2012 | Gus Cairns

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The search for a cure news selected from other sources

• HIV cure: scientific reality or media hype?

  Dr John Frater of the University of Oxford comments on recent HIV cure research.

  24 May 2013 | The Conversation

• Another Step Toward Eliminating HIV Infection?

  In two patients, allogeneic stem-cell transplantation under the cover of ART produced sustained reduction of HIV reservoirs in peripheral blood mononuclear cells.

  22 May 2013 | AIDS Clinical Care Journal Watch

• We can't allow the search for a cure for HIV to 'get in the way of access to antiretrovirals'

  Top AIDS scientists are in Paris to mark the 30th anniversary of the detection of HIV. One of them is Sharon Lewin. Her work on latent HIV cells could lead to a cure, but she warns it's a "tough ask."

  22 May 2013 | Deutsche Welle

• Françoise Barré-Sinoussi: the HIV hunter

  Thirty years ago, Françoise Barré-Sinoussi found an unidentified virus in a patient with Aids – work which won her a Nobel Prize. She talks about the continuing battle with the disease and her hopes of one day seeing a cure

  20 May 2013 | Financial Times

• UPDATE: Sangamo Highlights Encouraging Preliminary Anti-Viral HIV Data

  he data, which demonstrate that SB-728-T treatment results in a reduction in the HIV reservoir in HIV-infected subjects, are being presented at the 16^th Annual Meeting of the American Society of Gene and Cell Therapy (ASGCT).

  15 May 2013 | Benzinga

• No, HIV Is NOT About to Be Cured in Three Months

  David Evans of Project Inform dissects the hype around the UK Sunday Telgraph story that HIV would be cured "within months". Contrary to some hysterically hyped headlines this past week, HIV is not on the verge of being cured in the next three months, nor have scientists found an effective vaccine. The truth is that a hopeful compound to force HIV out of hiding is under study, and the results should be known in the near future.

  10 May 2013 | thebody.com

• Misleading News Reports Suggest HIV Cure Is Near

  Numerous news outlets have inaccurately reported that Danish researchers are, according to one publication, “within months” of finding a cure for HIV.

  10 May 2013 | AIDSMeds

• IAS 2013 conference programme now available online

  Strategies for pursuing a HIV cure, the impact of starting antiretroviral therapy at higher CD4 counts and innovative models for HIV testing and care are among the scientific topics featured in the IAS 2013 programme.

  08 May 2013 | International AIDS Society

• "Scientists on brink of HIV cure": correction

  The Telegraph's title and subtitle suggested that a cure for HIV is expected in months. But this is not the case, according to the Danish researchers from Aarhus University Hospital whose work was cited by the paper.

  08 May 2013 | Aarhus University Hospital press release

• UD-led team develops mathematical model to measure hidden HIV

  UD assistant professor Ryan Zurakowski has reported a new modeling technique that reveals HIV may be replicating in the body even when undetectable in the blood.

  08 May 2013 | University of Delaware Daily

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