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  • Beyond the Berlin patient – seeking a cure for HIV-AIDS

    Researchers from many corners of the world, including the Nobel Prize winning co-discoverer of the AIDS virus Françoise Barré-Sinoussi, are in Seattle this week to explore the possibility of curing people of HIV.

    14 hours ago | Humanosphere
  • HIV Antibodies Block Infection by Reservoir-Derived Virus in Laboratory Study

    The researchers conclude that passive immunotherapy involving bNAbs individually or in combination may control HIV in the absence of antiretroviral therapy. A number of clinical trials are already underway or planned to test this hypothesis.

    27 August 2014 | National Institutes of Allergy and Infectious Diseases press release
  • A voice for HIV cure: Scientists, activists gather for Hutch conference

    Matt Sharp is no scientist. But when he joins researchers from around the country tomorrow for a conference on using gene therapy to cure HIV, he will bring a perspective that few others in the room can match.

    26 August 2014 | Fred Hutchinson Cancer Research Center press release
  • Protein tethers HIV and Ebola to cells

    A family of proteins that helps viruses, such as HIV and Ebola, enter a cell also can block the release of those viruses. When HIV-1 or any virus infects a cell, it replicates and spreads to other cells. One type of cellular protein—T cell immunoglobulin and mucin domain, or TIM-1—has previously been shown to promote entry of some highly pathogenic viruses into host cells. Researchers have now discovered that the same protein possesses a unique ability to block the release of such viruses. The findings are published in the Proceedings of the National Academy of Sciences. “This is a surprising finding that provides new insights into our understanding of not only HIV infection, but also that of Ebola and other viruses,” says Shan-Lu Liu, associate professor of molecular microbiology and immunology at University of Missouri.

    26 August 2014 | Futurity
  • The Big Picture of Small Molecules for Curing HIV Infection

    Dr. David Margolis and Karine Dubé of The Martin Delaney Collaboratory of AIDS Researchers for Eradication explain one strategy being pursued by scientists as a possible way to cure HIV. After reading this, if you want to learn more check out this video on related research.

    22 August 2014 | AVAC
  • Vault nanoparticles engineered at UCLA show promise for cancer treatment and possible HIV cure

    UCLA scientists developed a method for placing bryostatin 1 in nanoscale vaults for safe delivery to cells, where it can activate latent HIV, enabling the virus to be eradicated.

    22 August 2014 | UCLA press release
  • iCo Therapeutics Announces Positive Oral Amphotericin B Study Results

    iCo Therapeutics Inc. ("iCo" or "the Company") today reported results of its Oral Amphotericin B (Oral Amp B) drug candidate targeting latent HIV reservoirs.

    22 August 2014 | iCo Therapeutics press release
  • 2000-Fold Drop in Latent Reservoir Needed for 1 Year Without ART

    About a 2000-fold reduction in the HIV reservoir in resting CD4 cells may be needed to let most people stop antiretroviral therapy (ART) for a single year without rebound, according to results of a modeling study. Predicted large variations in rebound times after ART stops mean close monitoring will be required for this strategy.

    21 August 2014 | International AIDS Society
  • How HIV co-opts gut bacteria to pose as a familiar infection

    One of the most effective methods used by HIV to evade control is to hide from the immune system. B-cells are crucial for controlling new infections, producing specific antibodies to attack it, which coat the surface of infected cells and tag them for destruction. But according to a study from Duke Medicine, published in Cell Host & Microbe, when HIV enters and begins replicating in the gut, the reaction of B cells is ineffective because the virus is able to pose as a “good” bacterium. Its gp41 surface protein - which is displayed on the surface of infected cells - looks like surface proteins on the cells of friendly gut bacteria.

    21 August 2014 | The Conversation UK
  • 'Shock and kill' approach cures mice of HIV in world first

    A combination of four drugs can flush out HIV-infected cells from hidden reservoirs in the body and kill them with a boost to the immune system, according to research published in the journal Cell today.

    18 August 2014 | The Conversation
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