The search for a cure

The search for a cure features

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  HIV gene therapy

  In April’s HTU, we featured a news story, reporting that a group of patients had had their CD4 counts boosted by a form of gene therapy – and...

  From:HIV treatment update

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  Towards a cure for all: How we might do it

  In the second part of this two-part feature, Gus Cairns investigates current research into finding a cure for HIV....

  From:HIV treatment update

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  Towards a cure for all (part one)

  For the first time, someone has been cured of HIV infection. It was a brutal and expensive procedure but, as Gus Cairns reports, in the first of a...

  From:HIV treatment update

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  The cure

  Could we eliminate HIV from the body altogether? Keith Alcorn looks at the latest milestones in a long journey of discovery. ...

  From:HIV treatment update

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  A ‘functional cure’?

  Examining the excitement over a bone marrow transplant that ‘eradicated’ HIV, by Edwin J Bernard. ...

  From:HIV treatment update

The search for a cure news from aidsmap

• Gene therapy for HIV is “progress towards functional cure” say researchers

  Investigators of a new gene therapy approach to HIV treatment claim that their findings represent “significant progress towards a `functional cure`”, after results from Sangamo Biosciences phase 1 study of SB-728-T showed no evidence of viral rebound after treatment ...

  20 September 2011 | Keith Alcorn

• Cell-to-cell spread of HIV keeps viral reservoir going despite ART

  The presence of very low levels of HIV in the blood despite treatment with highly potent antiretroviral regimens could be explained by cell-to-cell spread of the virus that overwhelms drug concentrations within cells, according to new research from the ...

  17 August 2011 | Keith Alcorn

• Novel vaccine did not protect monkeys against infection – but may have cured them

  A novel vaccine using the common virus Cytomegalovirus (CMV) as the vector or container of proteins from the simian immunodeficiency virus (SIV) protected none of a group of 24 rhesus macaques from infection. But in 13 of ...

  19 May 2011 | Gus Cairns

• Gold-based drug shows promise in clearing HIV reservoir in monkey study

  A gold-based drug already used for treatment of rheumatoid arthritis significantly reduced the reservoir of viral DNA and the population of long-lived HIV-infected memory CD4+ cells in a study conducted in six monkeys, Italian and American researchers report in the ...

  20 April 2011 | Keith Alcorn

• Stem cell transplant has cured HIV infection in 'Berlin patient', say doctors

  Doctors who carried out a stem cell transplant on an HIV-infected man with leukaemia in 2007 say they now believe the man to have been cured of HIV infection as a result of the treatment, which introduced stem cells ...

  13 December 2010 | Keith Alcorn

• Cure for HIV infection must now be major scientific priority, Vienna AIDS conference hears

  A cure for HIV infection is scientifically feasible and increasingly necessary, but the goal requires focus and funding, said Sharon Lewin of Monash University in Melbourne, in a keynote address at the opening session of the AIDS 2010 conference ...

  19 July 2010 | Liz Highleyman

• HIV cure efforts severely underfunded, US activists report

  Only 3% of the US AIDS research budget is currently devoted to efforts to find a cure for HIV infection, according to a new report from the AIDS Policy Project. Research funding for a cure is ...

  13 July 2010 | Keith Alcorn

• New grants for HIV cure research

  amfAR, the Foundation for AIDS Research, this week announced substantial new grants for research designed to determine whether a cure for HIV infection is possible. “amfAR has a long history of funding breakthrough research, and developing this ...

  13 May 2010 | Press Release

• Ho refuses to give up hope of eradicating HIV

  In a coded riposte to last week’s announcement that US treatment guidelines will shift towards later treatment, David Ho told last week’s Eighth Annual Conference on Retroviruses that "it is unclear to me whether we can ...

  05 March 2001 | Keith Alcorn

• New test for HIV waste products will identify more effective regimens; Ho argues eradication still possible

  A new test developed at the University of Massachusetts Medical School and the Hammersmith Hospital in London could help researchers identify HAART regimens which can truly halt HIV replication in the body, according to a report ...

  05 March 2001 | Keith Alcorn

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The search for a cure news selected from other sources

• Immune cells use 'starvation tactics' on HIV

  Scientists have shown how some cells in the body can repel attacks from HIV by starving the virus of the building blocks of life. Viruses cannot replicate on their own; they must hijack other other cells and turn them into virus production factories.

  12 February 2012 | BBC News

• Sangamo BioSciences Announces Initiation of Two New Phase 2 HIV Clinical Trials

  Sangamo BioSciences, Inc. announced today the initiation of two new Phase 2 clinical studies (SB-728-1101 and SB-728-902, Cohort 5) in its program to develop a "functional cure" for HIV/AIDS.

  09 January 2012 | PR Newswire

• Two Major Pharmaceutical Companies Take the Lead for an HIV Cure

  Gilead and Tibotec Janssen executives told the Fifth International Workshop on HIV Persistence, Reservoirs & Eradication Strategies that finding an HIV cure is a major research priority for each company. Both companies have developed in vitro models of HIV latency and are intensely screening libraries of compounds to attack HIV in its last hiding places.

  13 December 2011 | HIV-reservoir.net

• Monkey Study at HIV Persistence Workshop Offers Hope for Functional Cure

  Researchers meeting this week at the International Workshop on HIV Persistence, Reservoirs and Eradication Strategies in St Maarten heard about a small study of macaque monkeys which showed that a multidrug strategy targeting the viral reservoir lowered levels of SIV (a simian virus similar to HIV) and allowed the animals to remain off antiretroviral drugs for 3 months -- in effect a short-term functional cure.

  12 December 2011 | HIVandHepatitis.com

• HIV cure is the next frontier

  "Cure is the next frontier," said Rowena Johnston, vice president for research at amfAR, the Foundation for AIDS Research. "We want to make 'cure' into a family-friendly four-letter word."

  01 December 2011 | Bay Area Reporter

• New Hope of a Cure for HIV

  Medical researchers are again in pursuit of a goal they had all but abandoned: curing AIDS.

  28 November 2011 | New York Times

• HIV Cure-Related Clinical Research Workshop

  The AIDS Policy Project, Foundation for AIDS Research (amFAR), Project Inform, and the Treatment Action Group (TAG) have produced a new report on HIV cure-related research.

  02 November 2011 | Treatment Action Group

• HIV vaccine is a small breakthrough, but not a cure

  

  Tests produced encouraging results for researchers in Spain, but the eradication of this disease is still a long way off.

  29 September 2011 | The Guardian

• Scientists find way to "disarm" AIDS virus

  Researchers from the United States and Europe working in laboratories on the human immunodeficiency virus (HIV) found it is unable to damage the immune system if cholesterol is removed from the virus's membrane.

  "It's like an army that has lost its weapons but still has flags, so another army can recognize it and attack it," said Adriano Boasso of Imperial College London, who led the study.

  20 September 2011 | Reuters

• "Functional Cure" For HIV/AIDS Glimpsed In Small Trial

  Researchers testing a potential new gene therapy for HIV/AIDS say they are excited by early results that represent significant progress towards a "functional cure" for the disease.

  19 September 2011 | HIV / AIDS News From Medical News Today

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