The need for expert interpretation

One of the problems with implementing resistance testing in clinical practice will be ensuring correct interpretation of genotypic test results. Several methods of analysis have been used with varying degrees of success: expert analysis; computer analysis of genotypic data to produce a 'virtual phenotype'; and an algorithmic approach (a set of clear-cut rules) which doctors can use to assess genotypic results.

The GART study, as noted above, showed greater benefit when expert interpretation was used. 1

The HAVANA study randomised 326 patients failing treatment to receive one of the following:

  • Genotypic resistance testing with interpretation from an expert panel.
  • Genotypic resistance testing, no interpretation.
  • Standard of care based on medical history with advice from an expert.
  • Standard of care based on medical history without expert advice.

People who received treatment based on genotypic testing with expert interpretation had the best viral load response. 2

References

  1. Baxter JD et al. A randomized study of antiretroviral management based on plasma genotypic antiretroviral resistance testing in patients failing therapy. CPCRA 046 Study Team for the Terry Beirn Community Programs for Clinical Research on AIDS. AIDS 14: F83-F93, 2000
  2. Tural C et al. Clinical utility of HIV-1 genotyping and expert advice: the Havana trial. AIDS 16: 209-218, 2002
Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.