Side-effects

The most important side-effect of delavirdine is a skin rash that appears in 18 to 30% of people soon after starting the drug.1 The rash is occasionally accompanied by fever and lesions on the lips, mouth and genitals, lasting about three weeks. The rash is not usually severe and most people can continue the treatment. In clinical trials, approximately 5% of volunteers stopped delavirdine due to rash. Other side-effects include mild-to-moderate headache, fatigue, nausea, diarrhoea, and reversible liver abnormalities.

References

  1. Davey RT et al. Randomized, controlled phase I / II, trial of combination therapy with delavirdine (U-90152S) and conventional nucleosides in human immunodeficiency virus type-1 infected patients. Antimicrob Agents Chemother 40: 1657-1664, 1996
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