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  • 'Super-gonorrhoea' outbreak across north of England sparks national alert

    An outbreak of highly drug-resistant gonorrhoea has been detected in the north of England, triggering a national alert. Fifteen cases, all in heterosexuals, have been detected by Public Health England (PHE) so far, the British Association for Sexual Health and HIV said.

    18 September 2015 | Daily Telegraph
  • Can we ensure adherence to STI treatment guidelines in a world threatened by antimicrobial resistance?

    Sexual health care in the UK has traditionally centred on specialist GUM (genito-urinary medicine) services. Since the turn of the twenty-first century primary care has played an increasing role, however. The 2012 Health and Social Care Act is in line with this tendency, with most GP practices now being commissioned to provide level 1 STI screening. Questions have recently been raised about the conformity of care provided by GPs to national guidelines, established for the UK by the British Association for Sexual Health and HIV. In a world where Gonorrhoea – and perhaps one day Chlamydia – is set to become increasingly hard to treat, the problem of ensuring the conformity of generalists to universal standards of treatment is unlikely to go away.

    26 August 2015 | BMJ
  • Pretreatment HIV drug resistance leads patients to switch to second-line ART

    Recent data suggested that retreatment HIV drug resistance in sub-Saharan Africa was associated with a nearly fourfold increase in switching to second-line ART, but did not influence mortality or AIDS-related events.

    11 August 2015 | Healio
  • Limited Number of Mutations Responsible for Drug-Resistant HIV

    "What we are showing is that the rates of transmitted drug-resistant HIV in the low- and middle-income countries most affected by HIV have increased modestly. The rate of increase in sub-Saharan Africa has been low, and an increase has not been detected in south Asia and Southeast Asia. That's good news," said Robert Shafer, M.D., professor of medicine at Stanford and principal investigator on the study.

    08 April 2015 | Genetic Engineering & Biotechnology News
  • Exploring possible treatment options after virological failure with raltegravir

    In general, the integrase ihibitors raltegravir and dolutegravir have potent anti-HIV activity and have relatively few interactions with other drugs. However in clinical trials of raltegravir, strains of HIV that can resist raltegravir have emerged in up to 60% of heavily treatment-experienced people, and up to 8% of participants who have never taken HIV drugs before. A study in France of patients who had virologial failure to HIV therapy while taking raltegravir has found that 61% had HIV that was still susceptible to all integrase inhibitors. In cases where HIV was resistant to raltegravir, 14% were also resistant to dolutegravir.

    21 January 2015 | CATIE
  • New anti HIV drug dolutegravir is effective at low doses

    The new anti-HIV integrase inhibitor dolutegravir is a highly potent drug. Alain Lafeuillade, a clinical researcher for 20 years in HIV disease, observed that Dolutegravir is highly effective alone in patients without integrase resistance. "Plasma viral load remained undetectable in my patients, and proviral HIV DNA in cells remained stable with only 50 mg 2 to 3 times a week," he said. He is proposing a low-dose dolutegravir monotherapy trial.

    21 January 2015 | MMD Newswire
  • Drug Resistance, While Rare, Can Occur After Contracting HIV on PrEP

    For the first time, a study has shown that, although rare, resistance to Truvada can develop if someone contracts HIV while taking the drug as PrEP.

    16 January 2015 | AIDSMeds
  • Drug-resistant infections could lead to 10 million extra deaths a year – report

    The stark figures, published on Thursday, and believed to be the first to quantify the potential impact of antimicrobial resistance (AMR) – drug-resistant infections or superbugs – will be used to make the case to global leaders that urgent action is needed. To put the figures in context there are currently 8.2 million deaths a year from cancer and annual global GDP stands at $70tn to $75tn, with the UK figure around $3tn.

    11 December 2014 | The Guardian
  • An activist's guide to TB drugs

    TB treatment must be shorter, simpler, less toxic, and more tolerable and affordable. Activists can contribute to the development and uptake of improved TB treatment by calling attention to research, quality of medications, and access priorities.

    04 June 2014 | TAG
  • Transmitted HIV Resistance Rate Close to 20% in Large Study of US MSM

    More than 17% of antiretroviral-naive men who have sex with men (MSM) in a large US study carried antiretroviral-resistant virus, according to a nationwide analysis by the Centers for Disease Control and Prevention (CDC)]. MSM under 30 years old had close to a 19% prevalence of transmitted resistant HIV.

    06 March 2014 | NATAP
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