Pregnancy

The safety of Kaletra in pregnant women has not been established, but animal studies have shown some toxicity. Lopinavir also crosses the placenta, reaching effective anti-HIV levels in the foetus.1 Kaletra should not be used in pregnancy unless clearly necessary.

References

  1. Gavard L et al. Placental transfer of lopinavir / ritonavir in the ex vivo human cotyledon perfusion model. Am J Obstet Gynecol 195: 296-301, 2006
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