Pregnancy

The safety of 3TC (lamivudine, Epivir) in human pregnancy has not been definitively established. However, while animal studies have failed to show evidence of foetal malformations, studies in rabbits have shown that 3TC can cause death of the embryo in early pregnancy. Based on these studies, 3TC administration is not usually recommended for the first three months of pregnancy.

There is evidence that 3TC plus AZT (zidovudine, Retrovir) can significantly reduce mother-to-child transmission of HIV. A French study of 445 HIV-infected pregnant women found that the transmission rate was reduced to 2% when mothers took AZT and 3TC from week 32 of pregnancy until delivery and the combination was administered to the babies for the first six weeks of life1. However, the use of only two drugs by pregnant women may induce drug resistance and may undermine the benefits of subsequent antiretroviral treatment.

References

  1. Mandelbrot L et al. Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1. JAMA 285: 2083-2093, 2001
This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.