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  • HIV/AIDS drugs interfere with brain's 'insulation,' Penn-CHOP team shows

    In a new study, researchers from the University of Pennsylvania and The Children's Hospital of Philadelphia found that commonly used antiretroviral medications disrupted the function of oligodendrocytes, crucial brain cells that manufacture myelin, the fatty material that serves to insulate neurons, helping them transmit signals in the brain fast and efficiently.

    01 December 2015 | Eurekalert Medicine & Health
  • A New, More Reliable Way to Gauge HIV-Related Cognitive Dysfunction

    A new statistical means of assessing HIV-associated neurocognitive dysfunction (HAND) is more reliable than the so-called Frascati and Gisslén methods.

    06 May 2015 | AIDSMeds
  • Predictors of HIV-related peripheral neuropathy in the modern era

    Researchers at major clinical centres in the U.S. have collaborated to study potential causes of peripheral neuropathy (PN) among HIV-positive people in the modern era. They recruited about 500 people who were free from PN and monitored them for an average of two years, performing extensive assessments. Taking into account many issues, statistical analysis found that there were several factors associated with an increased risk for PN.

    01 April 2015 | CATIE
  • HIV can spread early, evolve in patients' brains

    HIV can genetically evolve and independently replicate in patients' brains early in the illness process, an analysis of cerebral spinal fluid has found. Prompt diagnosis and treatment with antiretroviral therapy should reduce the risk that the virus could find refuge and cause damage in the brain, where some medications are less effective -- potentially enabling it to re-emerge, even after it is suppressed in the periphery, say researchers.

    27 March 2015 | Eurekalert Inf Dis
  • Researchers identify key mechanisms underlying HIV-associated cognitive disorders

    New findings, published today by researchers at the University of California, San Diego School of Medicine, open the door to the development of new therapies to block or decrease cognitive decline due to HIV-associated neurocognitive disorders, estimated to affect 10 to 50 percent of aging HIV sufferers to some degree.

    04 February 2015 | Medical Xpress
  • Researchers identify key mechanisms underlying HIV-associated cognitive disorders

    New findings, published today by researchers at the University of California, San Diego School of Medicine, open the door to the development of new therapies to block or decrease cognitive decline due to HIV-associated neurocognitive disorders, estimated to affect 10 to 50 percent of aging HIV sufferers to some degree.

    04 February 2015 | Eurekalert Medicine & Health
  • Antiretroviral Neurotoxicity May Cause Cognitive Problems

    As many as 50% of those on combination antiretroviral therapy (cART) suffer from mild to moderate cognitive dysfunction. Antiretroviral medications themselves may be partly to blame for such neurocognitive problems, suggests a recent review of previous studies. But the authors of this review do not recommend that antiretroviral treatment be stopped.

    28 January 2015 | The Body Pro
  • Could HIV make hearing worse?

    A new study has found that low- and high-frequency hearing is poorer in adults with the human immunodeficiency virus, compared with adults who do not have the disease. Although unexpected, similar hearing loss has previously been observed to be more likely in adults with diabetes mellitus. "It is possible that both HIV infection and diabetes, being systemic diseases, could affect the neural function of the cochlea," the authors suggest.

    29 December 2014 | Medical News Today
  • Hepatitis C ruled out as cause of mental impairment in HIV patients

    “Hepatitis C infection has serious long-term side effects, such as damage to the liver, but our research indicates that it does not affect the brain,” said lead author David Clifford, MD, of Washington University.

    15 December 2014 | Washington University press release
  • Immune cells proposed as HIV hideout don't last in primate model

    The type of immune cell called macrophages, which have been proposed as a 'sanctuary site' of HIV in the brain and other organs, and as a possible cause of HIV-related brain impairment, don't live long enough to serve as reservoirs of HIV, a study in PLoS Pathogens finds.

    04 November 2014 | EATG
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