HIV-positive women who have endured a trauma such as emotional, physical or sexual abuse, or neglect earlier in their lives are more likely to have trouble remembering, paying attention or multitasking. Parts of their brains are also smaller than women who are only affected by HIV.
26 May 2016 | The Conversation
Turner and colleagues at Georgetown's Memory Disorders Program argue that the usual diagnosis of dementia in HIV patients -- HIV-associated neurocognitive disorder, or HAND -- might not be the whole picture. And if some patients present with HAND, Alzheimer's or a mixture, Turner told MedPage Today, clinicians will need to broaden their differential diagnosis to get the right therapy.
28 April 2016 | MedPage Today HIV/AIDS
Georgetown University researchers are reporting the first case of Alzheimer's disease diagnosed in an HIV-positive individual. The finding in a 71-year-old man triggers a realization about HIV survivors now reaching the age when Alzheimer's risk begins to escalate.
15 April 2016 | Eurekalert Inf Dis
These men, then in their 20s and 30s, weren’t supposed to make it to 40. Now some are 60 years old, even 70, still alive but wounded physically, psychologically and economically. They also are suffering debilitating health problems, chronic illnesses brought on by a lifetime of living with AIDS and the toxic effects of its treatment. Many live in stark isolation, feeling abandoned and forgotten, even by the gay community they helped build here.
11 March 2016 | San Francisco Chronicle
In a small, placebo-controlled clinical trial, Johns Hopkins physicians report that the antidepressant paroxetine modestly improves decision-making and reaction time, and suppresses inflammation in people with HIV-associated cognitive impairment.
26 February 2016 | Hopkins Medicine
In a new study, researchers from the University of Pennsylvania and The Children's Hospital of Philadelphia found that commonly used antiretroviral medications disrupted the function of oligodendrocytes, crucial brain cells that manufacture myelin, the fatty material that serves to insulate neurons, helping them transmit signals in the brain fast and efficiently.
01 December 2015 | Eurekalert Medicine & Health
A new statistical means of assessing HIV-associated neurocognitive dysfunction (HAND) is more reliable than the so-called Frascati and Gisslén methods.
06 May 2015 | AIDSMeds
Researchers at major clinical centres in the U.S. have collaborated to study potential causes of peripheral neuropathy (PN) among HIV-positive people in the modern era. They recruited about 500 people who were free from PN and monitored them for an average of two years, performing extensive assessments. Taking into account many issues, statistical analysis found that there were several factors associated with an increased risk for PN.
01 April 2015 | CATIE
HIV can genetically evolve and independently replicate in patients' brains early in the illness process, an analysis of cerebral spinal fluid has found. Prompt diagnosis and treatment with antiretroviral therapy should reduce the risk that the virus could find refuge and cause damage in the brain, where some medications are less effective -- potentially enabling it to re-emerge, even after it is suppressed in the periphery, say researchers.
27 March 2015 | Eurekalert Inf Dis
New findings, published today by researchers at the University of California, San Diego School of Medicine, open the door to the development of new therapies to block or decrease cognitive decline due to HIV-associated neurocognitive disorders, estimated to affect 10 to 50 percent of aging HIV sufferers to some degree.
04 February 2015 | Medical Xpress