Microbicides: latest news

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  • Microbicides

    Microbicides are any substances which protect people against infection by microbes, such as viruses or bacteria, on contact with those microbes....

    From: Preventing HIV

    Information level Level 4
  • Microbicides

    A microbicide is a topical agent that, when applied to a mucosal surface, serves as a barrier to infection. Microbicides can come in the form of...

    From: HIV transmission & testing

    Information level Level 4

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  • 'HIV gel' effective against herpes

    A microbicide gel initially intended to offer protection against HIV has been found to be effective against herpes. Herpes is one of the most common sexually transmitted diseases in South Africa. In the latest study, published in the New England Journal of Medicine, researchers from the Centre for the Aids Programme of Research in South Africa (Caprisa) showed that Tenofovir gel halved the risk of developing herpes simplex virus type 2 – a virus that is a leading cause of genital ulcers.

    13 August 2015 | Independent Online (South Africa)
  • Investment in post-efficacy R&D critical for PrEP, other new HIV prevention options

    HIV Prevention Research & Development Funding Trends 2000–2014: Investment Priorities To Fund Innovation In An Evolving Global Health And Development Landscape is the 11th annual report by the Working Group, a collaboration among AVAC, UNAIDS, and the International AIDS Vaccine Initiative (IAVI). The report summarizes investment in HIV prevention research across eight prevention options, as well as HSV-2 vaccine and HIV cure and therapeutic vaccine R&D.

    19 July 2015 | AVAC
  • Researchers complete ASPIRE Phase III trial of vaginal ring for HIV prevention in women

    In a first for HIV prevention, researchers have completed follow-up of participants in a pivotal Phase III trial that tested a vaginal ring for preventing HIV in women. The ring, which contains the ARV dapivirine, is meant to be worn for a month at a time. More than 2,600 African women took part in ASPIRE, one of two Phase III trials designed to support potential licensure of the ring. Results are expected early 2016.

    29 June 2015 | Eurekalert Medicine & Health
  • York trials new HIV prevention method

    Scientists at the University of York, in conjunction with the York Clinical Research Facility, will start the first phase of trials looking into a new way to prevent HIV transmission.

    18 February 2015 | HIV / AIDS News From Medical News Today
  • Failed Trial in Africa Raises Questions About How to Test HIV Drugs

    The failure of the VOICE trial of H.I.V.-prevention methods in Africa — and the elaborate deceptions employed by the women in it — have opened an ethical debate about how to run such studies in poor countries and have already changed the design of some that are now underway.

    05 February 2015 | New York Times
  • Uganda: High Hopes Ahead of Microbicide Trial Results

    HIV/Aids researchers are anticipating positive results from a large-scale trial assessing the efficacy of a vaginal microbicide gel in preventing HIV infection in women.

    21 January 2015 | AllAfrica.com
  • Cell-associated HIV mucosal transmission: The neglected pathway

    Dr. Deborah Anderson from Boston University School of Medicine and her colleagues are challenging dogma about the transmission of HIV. Most research has focused on infection by free viral particles, while this group proposes that HIV is also transmitted by infected cells. While inside cells, HIV is protected from antibodies and other antiviral factors. Anderson chides fellow researchers for not using cell-associated HIV in their transmission models: "The failure of several recent vaccine and microbicide clinical trials to prevent HIV transmission may be due in part to this oversight." . The Journal of Infectious Diseases (JID) has devoted their December supplement to this important and understudied topic.

    23 December 2014 | Medical News Today
  • Looking to a New Era for Women's HIV Prevention: Zeda Rosenberg

    Zeda Rosenberg, Chief Executive Offiver of the International Partnership for Microbicides, says: "While there is much progress to celebrate in HIV treatment and prevention, protecting women remains a major challenge. AIDS is the number-one killer of women ages 15 to 44 worldwide. Women are biologically more vulnerable to infection and face deep-rooted gender inequities that increase their risk. In sub-Saharan Africa, where the epidemic has taken the greatest toll, young women are at least twice as likely to contract HIV as young men."

    26 November 2014 | Huffington Post
  • As strategies to prevent HIV and unintended pregnancies evolve, concepts of “multi-purpose technologies” raise a familiar question . . .

    What do women want? While two trials test vaginal rings to fight HIV, market research highlights respondents’ interests in different options.

    14 November 2014 | Science Speaks
  • Semen directly impairs effectiveness of microbicides that target HIV

    Most microbicides work by targeting the virus itself, attempting to break it down or blocking its ability to infect a cell. However, the heightened infectiousness of HIV in the presence of semen appears to over-power any anti-viral effects the microbicides possess. The one exception to this finding is a different type of microbicide that acts on the host cells' receptors, stopping the virus from latching on from within. In the current study, this microbicide, [containing the drug called] called Maraviroc, was equally effective in preventing infection both with and without the presence of semen.

    13 November 2014 | MedicalXpress
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