Information sources on mutations

While no single source can ever be the sole definitive reference on HIV resistance mutations, a number of research groups track emerging resistance research data and maintain databases and publications that reflect current knowledge. These include:

• The UK Collaborative Group on HIV Drug Resistance maintains a central database of resistance test information from clinical practice throughout the United Kingdom. This information is used to track resistance prevalence and patterns throughout the UK. The Collaborative Group can be found online at www.hivrdb.org.uk.
• The International AIDS Society–USA Drug Resistance Mutations Group is an independent volunteer panel of the International AIDS Society–USA (IAS-USA) that monitors resistance patterns and has downloadable mutation charts on its website at www.iasusa.org/resistance_mutations/index.html.
• Stanford HIV Drug Resistance Database, online at http://hivdb.stanford.edu, allows the user to search its database by drug or mutation profile; gives mutation prevalence by subtype and treatment; analyses protease and/or RT sequences; and offers other tools to help guide regimen selection.