In a new study, scientists at The Wistar Institute have found that continued semen exposure in these sex workers sustains changes in the cervical and vaginal microenvironment in a way that may actually increase HIV-1 resistance. This information may lead the way to better preventative strategies that block the transmission of the virus and improved designs for future HIV vaccine studies that can monitor the described changes when recruiting sex workers into vaccine trials.
09 December 2015 | Eurekalert Inf Dis
FS surveyed 3,140 gay men and found 44% of HIV-negative men that would not have sex with an openly HIV-positive man. So we decided to reach out to these men and ask them directly, why?
02 December 2015 | FS
The benevolent powers of the vaginal microbiome are even greater than we thought. In addition to aiding fertilization and protecting fetuses during pregnancy, healthy vaginal mucus that’s full of good bacteria can trap and immobilize HIV particles. The study examined the cervicovaginal mucus, or CVM, of 31 women and tested its ability to immobilize HIV particles. CVM samples that contained higher concentrations of D-lactic acid, which only bacteria can produce, did far better than others. The D-lactic acid wasn’t itself a barrier to HIV, but an indicator of something else going on that made certain types of CVM better at trapping the virus than others.
That something was Lactobacillus crispatus, a species of bacteria that could change the way we think about HIV prevention.
08 October 2015 | Slate
HIV-1 infection with multiple founder variants points to poorer clinical outcomes than infection with a single variant, according to a paper published today in Nature Medicine. In the study researchers analyzed large sample sets from two important HIV vaccine efficacy trials -- the Step HIV vaccine clinical trial (HVTN 502) and RV144, the landmark vaccine clinical trial conducted in Thailand -- to evaluate whether genetic characteristics of the founder viral populations could influence markers of clinical outcomes.
01 September 2015 | Eurekalert Inf Dis
Why is one of the most common gynaecological conditions in sub-Saharan Africa, schistosomiasis, misunderstood, under-researched and under-reported? It is a significant risk factor for HIV acquisition in women.
06 July 2015 | 50.50
"The rigor of the placebo-controlled iPrEx trial gave us access to the necessary data and specimens to address that question. What we found was what people have been looking for, for a long time - a correlation between future infection risk and a measureable immune response."
23 June 2015 | Medical Xpress
New UCLA research offers further evidence that cocaine use disrupts the immune system, making people who use it more likely to become infected with HIV.
19 June 2015 | UCLA press release
Matthew Hodson, of UK-based gay men’s health charity, GMFA, explains why arguments for not having sex with gay men who are HIV positive make little sense – and could actually pose a danger for those who are HIV negative
09 April 2015 | Gaystar News
Postmenopausal women’s cervicovaginal fluid had lower anti-HIV-1 activity than premenopausal women. Timing of menstrual cycle and hormonal contraception were not associated with differences in activity against HSV or HIV.
30 March 2015 | 2 Minute Medicine
Dr. Deborah Anderson from Boston University School of Medicine and her colleagues are challenging dogma about the transmission of HIV. Most research has focused on infection by free viral particles, while this group proposes that HIV is also transmitted by infected cells. While inside cells, HIV is protected from antibodies and other antiviral factors. Anderson chides fellow researchers for not using cell-associated HIV in their transmission models: "The failure of several recent vaccine and microbicide clinical trials to prevent HIV transmission may be due in part to this oversight." . The Journal of Infectious Diseases (JID) has devoted their December supplement to this important and understudied topic.
23 December 2014 | Medical News Today