In addition to possibly being a component of the HIV reservoir, fat tissue may also be a source of harmful chronic inflammation among those living with the virus. Publishing their findings in PLOS Pathogens, researchers studied adipose (fat) tissue in both macaque monkeys infected with SIV, HIV’s simian cousin, as well as HIV-positive humans who underwent elective abdominal surgery.
28 September 2015 | Aidsmeds
HIV-1 infection with multiple founder variants points to poorer clinical outcomes than infection with a single variant, according to a paper published today in Nature Medicine. In the study researchers analyzed large sample sets from two important HIV vaccine efficacy trials -- the Step HIV vaccine clinical trial (HVTN 502) and RV144, the landmark vaccine clinical trial conducted in Thailand -- to evaluate whether genetic characteristics of the founder viral populations could influence markers of clinical outcomes.
01 September 2015 | Eurekalert Inf Dis
A study published on Aug. 20th in PLOS Pathogens of antiviral gene sequences in African monkeys suggests that lentiviruses closely related to HIV have infected primates in Africa as far back as 16 million years.
21 August 2015 | Eurekalert Inf Dis
Cheap and rapid test allows doctors to access list of every virus that has infected or continues to infect a patient, and could transform disease detection
05 June 2015 | New Scientist
When Peter Parham’s postdoc first showed him data suggesting a gene in some wild chimpanzees infected with the AIDS virus closely resembled one that protects humans from HIV, he was skeptical.
29 May 2015 | Science
As HIV investigators work to control and eradicate the virus worldwide, certain myths or misconceptions about the disease have been embraced, whereas other concepts with merit have been left relatively unexplored, argues American HIV/AIDS researcher Jay Levy, M.D., in a Trends in Molecular Medicine commentary. He calls on fellow researchers to continue questioning and not to lose sight of alternative strategies that could ultimately lead to a sustainable, long-term solution to HIV infection.
15 April 2015 | Eurekalert Inf Dis
A new model for HIV progression finds that it spreads in a similar way to some computer worms and predicts that early treatment is key to staving off AIDS. HIV specialists and network security experts at UCL noticed that the spread of HIV through the body using two methods -- via the bloodstream and directly between cells -- was similar to how some computer worms spread through both the internet and local networks respectively to infect as many computers as possible.
07 April 2015 | Eurekalert Inf Dis
HIV can genetically evolve and independently replicate in patients' brains early in the illness process, an analysis of cerebral spinal fluid has found. Prompt diagnosis and treatment with antiretroviral therapy should reduce the risk that the virus could find refuge and cause damage in the brain, where some medications are less effective -- potentially enabling it to re-emerge, even after it is suppressed in the periphery, say researchers.
27 March 2015 | Eurekalert Inf Dis
It’s now clear, researchers say, that HIV originated in humans on 13 separate occasions, evolving in humans from ancestral viruses that infected monkeys, chimpanzees and gorillas.
03 March 2015 | New York Times
Two of the four known groups of human AIDS viruses (HIV-1 groups O and P) have originated in western lowland gorillas, according to an international team of scientists. HIV-1, the virus that causes AIDS, has jumped species to infect humans on at least four separate occasions, generating four HIV-1 lineages -- groups M, N, O, and P. Previous research from this team found that groups M and N originated in geographically distinct chimpanzee communities in southern Cameroon, but the origins of groups O and P remained uncertain.
03 March 2015 | Eurekalert Inf Dis