Thanks to combination antiretroviral therapy, many people with HIV can be expected to live decades after being infected. Yet doctors have observed that these patients often show signs of premature aging. Now a study published April 21 in Molecular Cell has applied a highly accurate biomarker to measure just how much HIV infection ages people at the biological level -- an average of almost 5 years.
22 April 2016 | Eurekalert Inf Dis
Scientists have identified a human (host) protein that weakens the immune response to HIV and other viruses. The findings have important implications for improving HIV antiviral therapies, creating effective viral vaccines, and advance a new approach to treat cancer.
15 April 2016 | Science Daily
A primer on the harms of HIV-related chronic inflammation, what treatments are being researched and what you can do to reduce inflammation and improve your long-term health.
06 April 2016 | Poz
A study published in PLOS Pathogens suggests that it is not a general weakening of the immune system by HIV that initially leads to loss of Mtb control, but rather that HIV is associated with a failure to prevent harmful immune responses. As HIV disease progresses, the weakening immune system's focus on antiviral responses leaves it largely defenseless against the Mtb pathogen.
18 March 2016 | HIV / AIDS News From Medical News Today
HIV infection also can lead to diseases affecting the intestines, with increased gastrointestinal (GI) inflammation, diarrhea and problems with nutrient absorption. The role of gut microbes in such issues is not completely understood, but now, in two studies led by researchers at Washington University School of Medicine in St. Louis, scientists have identified intestinal bacteria and viruses as possible sources of such inflammation and disease.
11 March 2016 | HIV / AIDS News From Medical News Today
HIV-1 infection with multiple founder variants points to poorer clinical outcomes than infection with a single variant, according to a paper published today in Nature Medicine. In the study researchers analyzed large sample sets from two important HIV vaccine efficacy trials -- the Step HIV vaccine clinical trial (HVTN 502) and RV144, the landmark vaccine clinical trial conducted in Thailand -- to evaluate whether genetic characteristics of the founder viral populations could influence markers of clinical outcomes.
01 September 2015 | Eurekalert Inf Dis
Inflammation is the generic term for the body’s response to injury. During injury, the immune system—our body’s defense system—activates a complicated network of cells and chemical signals. Acute inflammation, immune activation that’s rapid and self-limited, is essential for healing. But chronic inflammation, immune activation that continues even after the initial injury is gone, is problematic. Chronic inflammation is like a volume control knob on a stereo being stuck—with the volume turned all the way up.
24 August 2015 | BETA blog
A research team at the IRCM, led by molecular virologist Éric A. Cohen, PhD, made a significant discovery on how HIV escapes the body’s antiviral responses. The team uncovered how an HIV viral protein known as Vpu tricks the immune system by using its own regulatory process to evade the host’s first line of defence. The findings, published yesterday in the scientific journal PLOS Pathogens, pave the way for future HIV prevention or cure strategies.
16 July 2015 | Institut de Recherches Cliniques de Montreal
A research team led by Weill Cornell Medical College scientists has discovered a way to limit replication of the most common form of HIV at a key moment when the infection is just starting to develop. The study, published June 25 in Nature Communications, has shed light on a potential new element of human immunity against HIV-1 and could provide a powerful new strategy — perhaps as part of an HIV vaccine — to limit the severity of the disease.
26 June 2015 | Weill Cornell Medical College
After finding out that I was an elite controller, I felt a lot of confusion. I knew what an elite controller was, but that didn’t translate to knowing what it actually meant to be one. I wasn’t new to the HIV world—I had previously been involved in HIV research—but I felt like I knew nothing about what was going on in my own body.
24 June 2015 | BETA blog