Hepatitis C co-infection

Studies have yielded conflicting results on the effect of hepatitis C/HIV co-infection on lipodystrophy. Earlier studies had found that co-infection was a risk factor for lipodystrophy. 1 2 However, an analysis of 1183 HIV-positive participants in the FRAM study did not find co-infection to be a risk factor for body fat changes; in fact, co-infected men had more leg fat and tended to lose it more slowly than HIV-positive men without HCV infection; co-infected women had more visceral fat than women without HCV. 3

References

  1. Duong M et al. Association between insulin resistance and hepatitis C virus chronic infection in HIV-hepatitis C virus-coinfected patients undergoing antiretroviral therapy. J Acquir Immune Defic Syndr 27: 245-250, 2001
  2. Galli M et al. Body habitus changes and metabolic alterations in protease inhibitor-naïve HIV-1 infected patients treated with two nucleoside reverse transcriptase inhibitors. J Acquir Immune Defic Syndr 29: 21-31, 2002
  3. Tien PC et al. Association between hepatitis C virus coinfection and regional adipose tissue volume in HIV-infected men and women. Immune Defic Syndr 45:60-65, 2007
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