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UGA researchers discover potential treatment for drug-resistant tuberculosis

The compound Nair and his colleagues developed works by binding to magnesium and specific amino acids found within the bacterium, interrupting the production of RNA. They were surprised to discover through preliminary experiments that it also exhibited strong anti-HIV properties, opening the door for dual therapeutic applications.

Published
20 February 2015
From
University of Georgia press release
Addressing TB and drug-resistant TB in the Eastern Ukrainian region

The challenges in addressing the implementation of comprehensive HIV, TB and viral hepatitis prevention and treatment activities in the Eastern Ukraine affected by the warfare is complicated and escalating every week.

Published
11 February 2015
From
Stop TB Partnership
Access sought to tuberculosis drug from nutraceutical company

Delamanid, only the second tuberculosis drug approved in 40 years by European regulators, uses a new mechanism of action to treat the disease by inhibiting the synthesis of a cell-wall component of Mycobacterium tuberculosis, the bacterium that causes tuberculosis. But patient advocates worry that the new drug may not reach the patients who need it because, according to these advocates, the developer of the drug has failed to aggressively study and market the medication in regions that need it most.

Published
05 February 2015
From
Nature Medicine
Zimbabwe Faces Troubling Spike in Cases of Multi-Drug Resistant TB

MDR-TB occurs when a strain of TB bacteria becomes resistant to two or more “first-line” antibiotic drugs prescribed to combat standard TB. According to the Ministry of Health and Child Welfare, cases of MDR-TB nearly doubled from 156 in 2011 to 244 cases in 2013. This was despite the fact that notifications for ordinary TB drastically declined from 47,000 in 2010 to 38,367 in 2012.

Published
26 January 2015
From
Inter Press Service
Recent Ukranian Tuberculosis Outbreak Due to Lack of Medicine

At a press conference convened by the AIDS Healthcare Foundation Ukraine today, a group of patients, experts and activists delivered a strong message that the country is experiencing a preventable tuberculosis (TB) outbreak this year due to the failure of state procurements to obtain essential medications. Activists urged that immediate measures be taken to address the crisis, including distributing needed medical supplies, creating transparent procurement systems and assessing the effectiveness of TB treatment for each patient in accordance to international standards.

Published
15 January 2015
From
AIDS Healthcare Foundation press release
Johnson & Johnson announces collaboration between Janssen and USAID to expand access to anti-multidrug-resistant tuberculosis (MDR-TB) compound

Memorandum of Understanding signed to address the global health threat of antibiotic-resistant bacteria.

Published
12 December 2014
From
PR Newswire
Drug-resistant infections could lead to 10 million extra deaths a year – report

The stark figures, published on Thursday, and believed to be the first to quantify the potential impact of antimicrobial resistance (AMR) – drug-resistant infections or superbugs – will be used to make the case to global leaders that urgent action is needed. To put the figures in context there are currently 8.2 million deaths a year from cancer and annual global GDP stands at $70tn to $75tn, with the UK figure around $3tn.

Published
11 December 2014
From
The Guardian
Preliminary Data Show High Success Rate for Dramatically Shortened Multidrug-resistant TB Treatment Option

A nine-month treatment regiment for multidrug-resistant tuberculosis (MDR-TB) appears to be as effective as a 12-month regiment, according to data from two new studies being presented today at the 45th World Conference on Lung Health in Barcelona, Spain.

Published
31 October 2014
From
International Union Against Tuberculosis and Lung Disease
WHO interim guidance on the use of delamanid in the treatment of MDR-TB

A new TB drug with a novel mechanism of action – delamanid - is now available for treatment of adults with multidrug-resistant tuberculosis (MDR-TB). Delamanid was granted conditional approval by the European Medicine Agency in April 2014. Information about this new drug however remains limited, since it has only been through Phase IIb trial and studies for safety and efficacy. WHO is therefore issuing “interim policy guidance” that lists five conditions that must be in place if delamanid is used to treat adults with MDR-TB

Published
29 October 2014
From
World Health Organization
Success short treatment against drug-resistant tuberculosis confirmed

In what has become known as the Bangladesh regimen, ITM’s Armand Van Deun and colleagues developed a treatment of only 9 months. This regimen replaces the currently recommended treatment of 18 to 24 months. In 2010, the researchers reported that this treatment increased the success rate from 65% to 88% for MDR-TB patients in Bangladesh. The treatment is based on a combination of existing drugs.The researchers report a favourable outcome in roughly 85% of cases, in spite of increasing levels of serious second-line drug resistance. A smaller study in Niger confirmed the outstanding results of the shorter treatment.

Published
28 October 2014
From
Institute of Tropical Medicine
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