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Drug-resistant TB news

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Multidrug-resistant TB appears less transmissible in households than drug-susceptible TB

Some strains of multidrug-resistant tuberculosis (MDRTB) may have a lower fitness (be less capable of spreading) than drug-susceptible tuberculosis bacteria, according to a study published this week in PLOS Medicine.

Published
24 June 2015
From
Eurekalert Inf Dis
Large-scale study underscores value of routine Xpert testing on TB, MDR TB case finding

A study of more than 100,000 patients with suspected tuberculosis at 18 sites across India showed that routine testing using Xpert molecular technology rather than the most commonly used — and oldest — diagnostic tool of examining a sputum smear under a microscope, increased detection of TB by 39 percent and led to five times the rate of detecting resistance to a TB treatment medicine.

Published
28 May 2015
From
Science Speaks
First all-oral XDR-TB drug regimen trial launches in South Africa

The regimen is comprised of bedaquiline, which received provisional approval from the U.S. Food and Drug Administration in 2013 to treat drug-resistant tuberculosis, pretomanid a new type of antibacterial drug, and linezolid which is used off-label to treat TB.

Published
15 May 2015
From
Science Speaks
WHO moves to improve access to lifesaving medicines for hepatitis C, drug-resistant TB and cancers

WHO today published the new edition of its Model List of Essential Medicines which includes ground-breaking new treatments for hepatitis C, a variety of cancers (including breast cancer and leukaemia) and multi-drug resistant tuberculosis (TB), among others.

Published
11 May 2015
From
World Health Organization
Final fight pays off, XXDR-TB & HIV patient cured

Once an active case of extremely drug resistant (XXDR-TB) strain of tuberculosis or totally drug resistant (TDR) TB, 40-year-old Rashid Khan (name changed), has now been completely cured of his disease. Despite having total drug resistance and HIV infection, Khan got cured a few days ago. At one stage he was receiving a cocktail of 18–20 drugs between his HIV and TB regimes. But Bedaquiline made a huge difference in his treatment. He is off medicine now.

Published
24 March 2015
From
DNAIndia
MSF: More than a quarter of MDR-TB cases in Swaziland not caught by “front line of defense” in fighting the disease

The nonprofit medical humanitarian organization Médecins Sans Frontières is recommending that all patients in Swaziland who have tested positive for TB, but rapid molecular testing has found negative for drug-resistance undergo further testing, following findings that a mutation has made more than a quarter of multidrug-resistant strains undetectable by the widely used test.

Published
20 March 2015
From
Science Speaks
Lancet: Phase 2b trial results of novel TB regimen show potential to shorten treatment

A new tuberculosis (TB) drug regimen designed to improve options for TB therapy eliminated more bacteria from sputum than standard therapy, worked for people with multi-drug-resistant (MDR) TB, and did so in a quarter of the time, according to data from a phase 2b clinical trial published today in The Lancet. These results are published just as the global phase 3 clinical trial, STAND, designed to bring this regimen through the last stage of testing, has begun. The PaMZ regimen uses pretomanid, a new drug; moxifloxacin, an established antibiotic that is experimental as a TB treatment; and pyrazinamide, an established TB drug. Twenty percent of the TB patients enrolled in NC-002 also were co-infected with HIV and the PaMZ regimen appeared to be effective independent of HIV status. See also http://www.aidsmap.com/Novel-TB-regimen-could-reduce-treatment-duration/page/2892700/

Published
18 March 2015
From
Lancet (free registration required)
Tuberculosis and superbug strains 'ravaging' Europe, WHO warns

As many as 1,000 people a day in Europe contract tuberculosis, and slow progress against the disease coupled with rising drug resistance mean the region is unlikely to defeat it until next century, health officials said on Tuesday.

Published
17 March 2015
From
Reuters
UGA researchers discover potential treatment for drug-resistant tuberculosis

The compound Nair and his colleagues developed works by binding to magnesium and specific amino acids found within the bacterium, interrupting the production of RNA. They were surprised to discover through preliminary experiments that it also exhibited strong anti-HIV properties, opening the door for dual therapeutic applications.

Published
20 February 2015
From
University of Georgia press release
Addressing TB and drug-resistant TB in the Eastern Ukrainian region

The challenges in addressing the implementation of comprehensive HIV, TB and viral hepatitis prevention and treatment activities in the Eastern Ukraine affected by the warfare is complicated and escalating every week.

Published
11 February 2015
From
Stop TB Partnership
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