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CROI 2014: Researchers discuss HIV, aging, and frailty

People living with HIV are at greater risk of geriatric syndromes such as frailty and difficulty with daily activities than HIV negative people of the same age -- and this can have a significant effect upon their quality of life as they age, according to several studies presented at the 14th Conference on Retroviruses and Opportunistic Infections (CROI 2014) last month in Boston.

Published
08 April 2014
From
HIVandHepatitis.com
HIV Drug Linked to Low Bone Density in Babies

In a cohort study, babies of mothers taking tenofovir (Viread) had an average whole-body bone mineral content about 8 grams less than babies whose mothers did not use the drug, according to George Siberry, MD, of the National Institute of Child Health and Human Development in Bethesda, Md

Published
07 March 2014
From
MedPage Today
Primary care key to management of patients with HIV infection

The HIV Medicine Association of the Infectious Diseases Society of America has updated its HIV care guidelines to reflect the fact that people with HIV are now living normal life spans, and their physicians need to focus on preventive care, including screening for high cholesterol, diabetes and osteoporosis.

Published
14 November 2013
From
Eurekalert Inf Dis
TDF/FTC-to-ABC/3TC switch maintains viral suppression, eases bone markers

A switch from tenofovir/emtricitabine (TDF/FTC) to abacavir/lamivudine (ABC/3TC), both with atazanavir/ritonavir, maintained viral suppression through 48 weeks in a noninferiority analysis and improved bone and kidney markers. Four people in the ABC/3TC arm (2%) and one in the TDF/FTC arm (1%) had study-defined virologic failure by week 48.

Published
19 September 2013
From
NATAP
Bone loss and fracture risk are 'modest' among HIV+ people, linked to tenofovir, smoking, and HCV

Continued bone loss among HIV positive men with osteopenia was modest overall, but about 25% of those taking tenofovir (Viread, also in 4 antiretroviral coformulations) experienced significant loss, according to a recent study. A related meta-analysis found that HIV infection is associated with a modest likelihood of new fractures, with smoking and hepatitis C virus (HCV) coinfection further increasing the risk.

Published
07 June 2013
From
HIVandHepatitis.com
Bone mineral density below normal in children infected early with HIV

Bone mineral density was below the general population norm in US children perinatally infected with HIV and lower than in children perinatally exposed to HIV but uninfected.

Published
21 January 2013
From
International AIDS Society
HIV treatment interruption associated with reduced bone loss in SMART trial

People who stopped antiretroviral therapy in the SMART trial had less bone loss and lower levels of bone metabolism biomarkers than people who remained on continuous antiretroviral therapy (ART), according to a report in the January 8, 2013, advance edition of Journal of Bone Mineral Research.

Published
16 January 2013
From
HIVandHepatitis.com
Activist discusses challenge of growing old with HIV

Old age comes faster and hits harder for those infected with HIV, a fact aging health activist Ron Swanda knows all too well.

Published
30 November 2012
From
AFP
Weekly alendronate improves bone density in adults taking ART

Alendronate significantly improved bone mineral density through 96 weeks of treatment in a double-blind placebo-controlled trial that enrolled adults with osteoporosis while taking antiretroviral therapy (ART).

Published
30 August 2012
From
International AIDS Society
High Dose Vitamin D Prevents Fractures

High doses of vitamin D prevent fractures in older people – as long as they take the substance regularly.

Published
05 July 2012
From
Medical News Today
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