Drug interactions

Darunavir (Prezista) is broken down through the cytochrome 3A4 system in the liver.

People taking darunavir should not take the following drugs:

  • Alfuzosin
  • Astemizole
  • Carbamazepine (Tegretol)
  • Cisapride
  • Colchicine in people with renal or hepatic impairment
  • Dihydroergotamine
  • Ergonovine
  • Ergotamine tartrate (Cafergot / Migril)
  • Hypericin (St John’s wort)
  • Lovastatin
  • Methylergonovine
  • Midazolam (Hypnovel)
  • Phenobarbital
  • Phenytoin (Epanutin)
  • Pimozide (Orap)
  • Rifampicin (Rifadin / Rimactane)
  • Simvastatin (Zocor)
  • Terfenadine
  • Triazolam.

The following drugs may require a dose adjustment in people taking darunavir, or may require darunavir’s dose to be altered. Until more data are available they should be used with darunavir cautiously:

  • Atorvastatin (Lipitor)
  • Bepidril
  • Ciclosporin (Neoral / Sandimmun)
  • Dexamethasone
  • Efavirenz (Sustiva)
  • Felodipine (Plendil)
  • Fluticasone propionate (Flixotide)
  • Indinavir (Crixivan)
  • Itraconazole (Sporanox)
  • Ketoconazole (Nizoral)
  • Lidocaine
  • Methadone hydrochloride (Methadose)
  • Nicardipine hydrochloride (Cardene / Cardene SR)
  • Nifedipine (Adalat / Adalat LA / Adalat Retard / Adipine MR / Adipine XL / Cardilate MR / Coracten SR / Coracten XL / Fortipine LA 40 / Hypolar Retard 20 / Nifedipress MR / Nifopress Retard / Slofedipine / Slofedipine XL / Tensipine MR)
  • Paroxetine (Seroxat)
  • Pravastatin sodium (Lipostat)
  • Rifabutin (Mycobutin)
  • Ritonavir-boosted lopinavir (Kaletra)
  • Quinidine sulphate
  • Sertraline (Lustral)
  • Sildenafil (Viagra), a reduced dose is recommended. Sildenafil is contraindicated if used for treatment of pulmonary arterial hypertension.
  • Sirolimus (Rapamune)
  • Tacrolimus (Prograf)
  • Tadalafil (Cialis), a reduced dose is recommended
  • Trazodone hydrochloride (Molipaxin)
  • Vardenafil (Levitra), a reduced dose is recommended
  • Voriconazole (Vfend)
  • Warfarin sodium.

Women using ethinylestradiol or norethidrone as hormonal contraception may experience reduced levels of the contraceptive if they take darunavir. Additional or alternative methods of contraception are recommended.

Darunavir should not be taken with the hepatitis C direct-acting antivirals elbasvir/grazoprevir (Zepatier), simeprevir (Olysio), paritaprevir, ombitasvir and dasabuvir (Viekirax). No dose adjustment of other direct-acting antivirals is necessary.

Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.