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Could other drugs and delivery methods be used as PrEP?

So far most studies have examined the use of Truvada (tenofovir and emtricitabine) pills as PrEP. But PrEP using a single-drug regime of tenofovir could be possible and would be cheaper. One study found that it was only a little less effective than Truvada, with the difference not being statistically significant. The use of maraviroc and other antiretroviral drugs is being investigated.

Moreover, PrEP does not necessarily need to involve daily pills. Vaginal microbicide gels are also a form of PrEP, but adherence to these has been poor for a range of complex reasons.

It may also be possible to provide antiretrovirals through a vaginal ring which only needs to be replaced every month – this technology is already used for contraceptives and a single ring could potentially combine HIV prevention and contraception. Similarly, long-acting injections are also being investigated – these may provide protection for up to three months at a time.

PrEP

Published July 2015

Last reviewed July 2015

Next review July 2018

This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.
Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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This content was checked for accuracy at the time it was written. It may have been superseded by more recent developments. NAM recommends checking whether this is the most current information when making decisions that may affect your health.

NAM’s information is intended to support, rather than replace, consultation with a healthcare professional. Talk to your doctor or another member of your healthcare team for advice tailored to your situation.