Clinical trials: latest news

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  • Clinical trials

    This factsheet provides a brief introduction to the types of clinical trial that people with HIV might be asked to join. There is also information on how...

    From: Factsheets

    Information level Level 2
  • Thinking about joining a clinical trial?

    People decide to take part in clinical trials for different reasons. It is something that is best decided in close consultation with your healthcare team. Generally, it...

    From: Factsheets

    Information level Level 2

Clinical trials features

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  • Women are missing from HIV drug trials

    In an analysis spanning several decades that included work done as recently as 2012, researchers found that women typically comprised about 11 percent of participants in trials investigating cures for HIV. Similarly, drug studies were only about 19 percent female and just 38 percent of vaccine trial subjects were women.

    05 October 2015 | Reuters
  • Future of HIV cure research points to combination approach

    The next five years of HIV research should shift gears from the classic single-therapy development model to moving directly from in vitro studies to combination therapy trials, authors argue in a new paper published online today.

    01 October 2015 | US Military HIV Research Program press release
  • HIV patients should be included in early clinical trials of anti-TB drugs

    Tuberculosis is the number one cause of death in HIV-infected patients in Africa and a leading cause of death in this population worldwide, yet the majority of these patients are excluded from the early stages in the development of new, anti-tuberculosis drugs, according to research.

    01 October 2015 | Science Daily
  • U.S. Survey on Willingness to Participate in HIV Cure-Related Research: Your Opinion Matters (US readers only)

    There has been an increase in HIV cure research in the recent years. We would like to find out how people living with HIV (or potential HIV cure research volunteers) perceive HIV cure research, including their willingness to participate in HIV cure studies. We would also like to find out what would help implement HIV cure studies. Your answers to these questions will be kept strictly confidential.

    16 September 2015 | University of North Carolina
  • Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial

    The Lancet publishes the results of the PROUD PrEP study which were announced at the CROI conference on 24 February this year - full text PDF available open-access. See .

    10 September 2015 | The Lancet
  • Psychologists Welcome Analysis Casting Doubt on Their Work

    The field of psychology sustained a damaging blow Thursday: A new analysis found that only 36 percent of findings from almost 100 studies in the top three psychology journals held up when the original experiments were rigorously redone.

    01 September 2015 | New York Times
  • Scientists have the tools to end the HIV epidemic; they just need better ways to use them

    In the past, there was a sense that stopping the HIV/AIDS epidemic would require some radically new biomedical intervention, such as a cure or a vaccine. The growing consensus, however, is that the tools needed to stamp out HIV already exist if they could just be used in the right way.

    08 July 2015 | Nature
  • Leading Canadian researcher calls for inclusion of co-infected people in large HCV clinical trials

    Stephen Shafran from the University of Alberta performed a major review of clinical trials of many DAA-containing HCV therapies used for the treatment of HCV mono-infection as well as HIV-HCV co-infection. Cure rates of HCV are “remarkably similar” in HCV mono-infected and co-infected participants who were treated with the same regimen and who have the same strain (genotype) of HCV.

    07 July 2015 | CATIE
  • Risks vs rewards: why people with HIV volunteer for 'cure' research

    A recent survey of people living with HIV in the United Kingdom found that more than half would participate in a clinical study to develop a cure for HIV, despite this posing a risk to their health. Why would someone choose to do this?

    24 June 2015 | The Conversation
  • START Making Sense

    The story of the START trial will continue to be told for a long time to come. For some it will be a tale of rigorous perseverance in the face of strong counter-prevailing headwinds and ultimate arrival at a result that is solid and conclusive. Others will see a single-minded and aggressive defense of a trial by investigators who refused to accept not only the obvious but also the evidence that rendered their design obsolete and even unethical.

    19 June 2015 | North Carolina AIDS Training and Education Center
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