Bone problems

Bone problems features

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  Skeleton key: a guide to HIV-related bone loss

  Many people with HIV are at risk of osteoporosis – a progressive thinning of the bones that can lead to breakage. Derek Thaczuk looks at who...

  From:HIV treatment update

Bone problems news from aidsmap

• HIV treatment reduces risk of fractures

  Treatment with antiretroviral drugs reduces the risk of low-impact fractures, according to a case-controlled study published in the on-line edition of AIDS. Investigators compared fracture incidence between patients taking HIV therapy and non-treated individuals. Despite the overall beneficial effect of treatment, ...

  14 February 2012 | Michael Carter

• Vitamin D supplements benefit bone metabolism of younger patients taking tenofovir

  Vitamin D supplementation is associated with an improvement in a key marker of bone health in HIV-positive young adults treated with tenofovir, US research published in Clinical Infectious Diseases shows. Treatment with vitamin D3 led to a significant fall in parathyroid ...

  25 January 2012 | Michael Carter

• Limited evidence that vitamin D supplements of any benefit for patients with HIV

  There is only scant evidence that vitamin D supplementation is of benefit for patients with HIV, according to UK investigators writing in the January 28th  edition of AIDS. The authors conducted a systematic review of studies examining the prevalence ...

  10 January 2012 | Michael Carter

• Raltegravir kinder to bones and body fat than boosted protease inhibitors in Spanish trial

  Raltegravir (Isentress)-based treatment appears to have a more favourable impact on fat accumulation and bone metabolism compared to therapy based on a ritonavir-boosted protease inhibitor, according to Spanish research published in the online edition of AIDS. The study involved ...

  28 November 2011 | Michael Carter

• Patients on HIV therapy have an increased risk of stress and fragility fractures; no link to specific drug

  Patients taking antiretroviral therapy have an increased risk of fractures typically associated with low bone mineral density, Danish investigators report in the online edition of AIDS. However, the most important risk factors were the presence of other chronic illnesses and ...

  28 November 2011 | Michael Carter

• Raltegravir combined with Kaletra associated with good preservation of bone density over 96 weeks

  A two-drug antiretroviral combination comprising raltegravir and ritonavir-boosted lopinavir has only a modest impact on bone mineral density, a study presented to the International AIDS Society conference (IAS 2011) in Rome shows. The raltegravir (Isentress) and lopinavir/ritonavir (Kaletra) combination had ...

  19 July 2011 | Michael Carter

• Doubt remains if HIV therapy increases the risk of fragility fractures

  The relationship between HIV therapy and fracture risk is far from straightforward, US research presented to the International AIDS Society conference (IAS 2011) in Rome suggests. An analysis including over 56,000 HIV-positive military veterans who received care between 1988 and 2009 ...

  18 July 2011 | Michael Carter

• Marker of cardiovascular disease also associated with bone problems in patients with HIV

  An important marker of sub-clinical cardiovascular risk is associated with reduced bone mineral density in the hips of HIV-positive patients, according to Italian research presented to the Sixth International AIDS Society conference (IAS 2011) in Rome. The investigators found that ...

  18 July 2011 | Michael Carter

• Tenofovir and bone loss: treatment causes early changes in thyroid hormone levels

  Treatment with tenofovir increases levels of a hormone associated with calcium metabolism, Spanish investigators report in the online edition of AIDS Research and Human Retroviruses. This finding is a possible explanation for the reduced bone density seen in patients treated ...

  19 June 2011 | Michael Carter

• Low CD4 increases risk of fragility fractures for patients with HIV

  A low CD4 cell count is associated with an increased risk of fragility fractures in patients with HIV, an Australian study published in the online edition of the Journal of Acquired Immune Deficiency Syndromes shows. The retrospective, case-controlled study involved ...

  04 May 2011 | Michael Carter

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Bone problems news selected from other sources

• Zoledronate Protects HIV Positive Men against Bone Loss for at Least 5 Years

  The effects of 2 annual doses of zoledronate persist for at least 5 years in HIV positive men on antiretroviral therapy (ART), according to a New Zealand study published in the March 14, 2012, advance online edition of the Journal of Clinical Endocrinology & Metabolism.

  11 April 2012 | HIVandHepatitis.com

• CROI: Switching to Tenofovir Increases Bone Turnover, Raltegravir Can Improve Bone Density

  HIV positive people who substituted tenofovir (Viread) for zidovudine (AZT; Retrovir) in their antiretroviral regimen showed elevated levels of biomarkers associated with bone turnover and decreased bone mineral density (BMD), researchers reported at the 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012) last month in Seattle.

  11 April 2012 | HIVandHepatitis.com

• Vitamin D May Improve Bone Health in Those Taking Anti-HIV Drug

  A new NIH-funded study indicates that taking Vitamin D supplements can help prevent hormonal changes that lead to bone loss amongst patients taking tenofovir (Viread) for the long-term treatment of HIV.

  12 January 2012 | National Institutes of Health press release

• HIV Worsens Bone Loss After Menopause

  Compared to a control group, postmenopausal women with HIV infection had higher rates of bone loss and could well have a higher risk for fracture as they age, according to the researchers who conducted the study.

  03 January 2012 | Medscape (requires free registration)

• Children with HIV in Asia suffer resistance to AIDS drugs

  eenagers in Asia receiving treatment for HIV are showing early signs of osteoporosis and children as young as five are becoming resistant to AIDS drugs, an anti-AIDS group said on Thursday, urging more attention be given to young HIV patients.

  01 December 2011 | Reuters

• Panel Issues New Guidelines on Ideal Vitamin D Levels

  An expert panel has issued new recommendations suggesting that people with HIV might require two to three times the level of vitamin D as their HIV-negative peers.

  10 June 2011 | AIDSMeds.com

• Low Vitamin D Levels Are Common in Both HIV-Positive and HIV-Negative Women

  Though nearly two thirds of women in a large study had low vitamin D levels—a risk factor for bone and heart problems—the HIV-positive women were actually slightly less likely than HIV-negative women to be vitamin D deficient. 

  14 April 2011 | AIDSMeds

• Vitamin D levels linked with health of blood vessels

  A lack of vitamin D, even in generally healthy people, is linked with stiffer arteries and an inability of blood vessels to relax, researchers have found.

  03 April 2011 | Eurekalert Medicine & Health

• What Lies Ahead: An Activist's View of Promising HIV Treatment Research

  After attending the 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011) in Boston, Mass., and following different areas of research, I decided to write down a list of advancements that really thrill and energize me as an educator and research advocate.

  31 March 2011 | The Body

• Belly fat puts women at risk for osteoporosis

  (Radiological Society of North America) For years, it was believed that obese women were at lower risk for developing osteoporosis, and that excess body fat actually protected against bone loss. However, a new study found that having too much internal abdominal fat may, in fact, have a damaging effect on bone health.

  30 November 2010 | Eurekalert Medicine & Health

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